Related ArticlesNucleolus-Targeted Photodynamic Anticancer Therapy Using Renal-Clearable Carbon Dots. Adv Healthc Mater. 2020 Jun 16;:e2000607 Authors: Pang W, Jiang P, Ding S, Bao Z, Wang N, Wang H, Qu J, Wang D, Gu B, Wei X Abstract Photodynamic therapy (PDT), which utilizes light excited photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention...
Thu Jun 18, 2020 14:25
Related ArticlesRisk stratification in oral squamous cell carcinoma using staging of the eighth American Joint Committee on Cancer: Systematic review and meta-analysis. Head Neck. 2020 Jun 17;: Authors: Almangush A, Pirinen M, Youssef O, Mäkitie AA, Leivo I Abstract The eighth edition of the American Joint Committee on Cancer (AJCC8) staging manual has major changes in oral squamous cell carcinoma (OSCC). We searched PubMed, OvidMedline, Scopus, and...
Thu Jun 18, 2020 14:25
Related ArticlesHIP1R acts as a tumor suppressor in gastric cancer by promoting cancer cell apoptosis and inhibiting migration and invasion through modulating Akt. J Clin Lab Anal. 2020 Jun 16;:e23425 Authors: Zhu J, Wang X, Guan H, Xiao Q, Wu Z, Shi J, Zhang F, Gao P, Song Y, Wang Z Abstract BACKGROUND: Huntingtin-interacting protein 1-related (HIP1R) is a multi-domain gene that exerts many cellular functions including altering T cell-mediated cytotoxicity...
Thu Jun 18, 2020 14:25
Related ArticlesComputational Modeling of Interstitial Fluid Pressure and Velocity in Head and Neck Cancer Based on Dynamic Contrast-Enhanced Magnetic Resonance Imaging: Feasibility Analysis. Tomography. 2020 Jun;6(2):129-138 Authors: LoCastro E, Paudyal R, Mazaheri Y, Hatzoglou V, Oh JH, Lu Y, Konar AS, Vom Eigen K, Ho A, Ewing JR, Lee N, Deasy JO, Shukla-Dave A Abstract We developed and tested the feasibility of computational fluid modeling (CFM) based...
Thu Jun 18, 2020 14:25
Related ArticlesIn silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization. Front Chem. 2020;8:443 Authors: Michel M, Homan EJ, Wiita E, Pedersen K, Almlöf I, Gustavsson AL, Lundbäck T, Helleday T, Warpman Berglund U Abstract Computational chemistry has now been widely accepted as a useful tool for shortening lead times in early drug discovery. When selecting new potential drug targets, it is important...
Thu Jun 18, 2020 14:25
Related ArticlesMesothelin expression in esophageal adenocarcinoma and squamous cell carcinoma and its possible impact on future treatment strategies. Ther Adv Med Oncol. 2020;12:1758835920917571 Authors: Moentenich V, Comut E, Gebauer F, Tuchscherer A, Bruns C, Schroeder W, Buettner R, Alakus H, Loeser H, Zander T, Quaas A Abstract Background: Mesothelin is expressed at very low levels by normal mesothelial cells but is overexpressed in several human...
Thu Jun 18, 2020 14:25
Related ArticlesLooking for the Optimal PD-1/PD-L1 Inhibitor in Cancer Treatment: A Comparison in Basic Structure, Function, and Clinical Practice. Front Immunol. 2020;11:1088 Authors: Chen Y, Pei Y, Luo J, Huang Z, Yu J, Meng X Abstract Programmed cell death protein-1/ligand 1 (PD-1/L1) targeted immune checkpoint inhibitors have become the focus of tumor treatment due to their promising efficacy. Currently, several PD-1/PD-L1 inhibitors have been approved...
Thu Jun 18, 2020 14:25
Related ArticlesAnalysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells. Front Microbiol. 2020;11:1179 Authors: Ouwendijk WJD, Dekker LJM, van den Ham HJ, Lenac Rovis T, Haefner ES, Jonjic S, Haas J, Luider TM, Verjans GMGM Abstract Herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) are two closely related human alphaherpesviruses that persistently infect most adults worldwide and cause a...
Thu Jun 18, 2020 14:25
Skin Cancer May Delay Onset but Not Progression of Parkinson's Disease: A Nested Case-Control Study.
Related ArticlesSkin Cancer May Delay Onset but Not Progression of Parkinson's Disease: A Nested Case-Control Study. Front Neurol. 2020;11:406 Authors: Mahajan A, Chirra M, Dwivedi AK, Sturchio A, Keeling EG, Marsili L, Espay AJ Abstract Objective: To evaluate the extent to which cancer, a biological opposite to neurodegenerative disorders, may affect the onset and progression of Parkinson's disease (PD). Methods: A nested case-control design in consecutive...
Thu Jun 18, 2020 14:25
Related ArticlesProvince-specific smoking-attributable cancer mortality in China 2013. Tob Induc Dis. 2020;18:49 Authors: Yu L, Cheng J, Cui X, Wang J Abstract INTRODUCTION: Province-specific initiatives are at the forefront of tobacco control but limited studies have provided province-specific assessment of smoking-attributable cancer burden in China. METHODS: We estimated the fraction of total and site-specific cancer mortality attributable...
Thu Jun 18, 2020 14:25
Related ArticlesMini-Review: Cabozantinib in the Treatment of Advanced Renal Cell Carcinoma and Hepatocellular Carcinoma. Cancer Manag Res. 2020;12:3741-3749 Authors: Rathi N, Maughan BL, Agarwal N, Swami U Abstract Cabozantinib is an oral, tyrosine-kinase inhibitor with potent activity against VEGFR2 and MET, along with multiple other tyrosine kinases involved in cancer development and progression. Herein, we will focus on preclinical and clinical studies...
Thu Jun 18, 2020 14:25
Related ArticlesAdvances and Prospects of Vasculogenic Mimicry in Glioma: A Potential New Therapeutic Target? Onco Targets Ther. 2020;13:4473-4483 Authors: Cai H, Liu W, Liu X, Li Z, Feng T, Xue Y, Liu Y Abstract Vasculogenic mimicry (VM) is the formation of a "vessel-like" structure without endothelial cells. VM exists in vascular-dependent solid tumors and is a special blood supply source involved in the highly invasive tumor progression. VM is observed...
Thu Jun 18, 2020 14:25
Related ArticlesPatient Selection Strategies to Maximize Therapeutic Index of Antibody Drug Conjugates: Prior Approaches and Future Directions. Mol Cancer Ther. 2020 Jun 16;: Authors: Williams M, Spreafico A, Vashisht K, Hinrichs MJ Abstract Antibody drug conjugates (ADCs) are targeted agents that have shown promise in treating cancer. A central challenge in development of ADCs is the relatively narrow therapeutic index observed in clinical studies....
Thu Jun 18, 2020 14:25
Related ArticlesConcordance between predicted HLA type using next generation sequencing data generated for non-HLA purposes and clinical HLA type. Hum Immunol. 2020 Jun 13;: Authors: Moyer AM, Dukek B, Duellman P, Schneider B, Wakefield L, Skierka JM, Avula R, Bhagwate AV, Kalari KR, Kreuter JD, Goetz MP, Boughey JC, Black JL, Gandhi MJ Abstract We explored the feasibility of obtaining accurate HLA type using pre-existing NGS data not generated for HLA...
Thu Jun 18, 2020 14:25
Related ArticlesNeoadjuvant therapy for muscle-invasive bladder cancer. Expert Rev Anticancer Ther. 2020 Jun 16;: Authors: Jain RK, Sonpavde G Abstract INTRODUCTION: Muscle-invasive bladder cancer (MIBC) is generally a highly aggressive malignancy with early and mostly distant recurrences. Cisplatin-based combinations have been established as neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) providing overall survival as well as disease-free...
Thu Jun 18, 2020 14:25
Related ArticlesExercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial. J Clin Med. 2020 Jun 14;9(6): Authors: Santa Mina D, Dolan LB, Lipton JH, Au D, Camacho Pérez E, Franzese A, Alibhai SMH, Jones JM, Chang E Abstract People with cancer who undergo allogeneic hematological stem cell transplant (allo-HSCT) experience significant deconditioning that can compromise...
Thu Jun 18, 2020 14:25
Related ArticlesArtificial intelligence, chatbots, and the future of medicine. Lancet Oncol. 2019 Apr;20(4):481-482 Authors: Greene A, Greene CC, Greene C PMID: 30942174 [PubMed - indexed for MEDLINE]
Thu Jun 18, 2020 14:25
Publication date: Available online 18 June 2020Source: CortexAuthor(s): Anastasia Chalkia, Lukas Van Oudenhove, Tom Beckers
Thu Jun 18, 2020 14:22
Publication date: Available online 18 June 2020Source: CortexAuthor(s): Christopher D. Chambers
Thu Jun 18, 2020 14:22
Publication date: Available online 18 June 2020Source: CortexAuthor(s): Robert D. McIntosh, Christopher D. Chambers
Thu Jun 18, 2020 14:22
Publication date: Available online 18 June 2020Source: CortexAuthor(s): Anastasia Chalkia, Natalie Schroyens, Lu Leng, Niels Vanhasbroeck, Ann-Kathrin Zenses, Lukas Van Oudenhove, Tom Beckers
Thu Jun 18, 2020 14:22
Publication date: August 2020Source: World Neurosurgery, Volume 140Author(s): Neerav Anand Singh, Vibhu Krishnan Viswanathan, Ajoy Prasad Shetty, Rishi Mukesh Kanna, Shanmuganathan Rajasekaran
Thu Jun 18, 2020 14:20
Publication date: August 2020Source: Brain Research Bulletin, Volume 161Author(s):
Thu Jun 18, 2020 14:20
Publication date: Available online 17 June 2020Source: Brain Research BulletinAuthor(s): Zheng Dahai, Chen Daliang, Lin Famu, Wan Xiang, Lu Lenian, Chen Jianmin, Xu Xiaobing
Thu Jun 18, 2020 14:20
Publication date: Available online 17 June 2020Source: Brain Research BulletinAuthor(s): Zhi-Hong Li, Chun-Kui Zhang, Yu Qiao, Shun-Nan Ge, Ting Zhang, Jin-Lian Li
Thu Jun 18, 2020 14:20
Related ArticlesHow group coaching contributes to organisational understanding among newly graduated doctors. BMC Med Educ. 2020 Jun 16;20(1):193 Authors: Malling B, de Lasson L, Just E, Stegeager N Abstract BACKGROUND: Practising medicine at an expert level requires skills beyond medical expert knowledge. Research shows that newly appointed consultants feel less prepared to deal with leadership issues compared to issues regarding medical expertice....
Thu Jun 18, 2020 14:20
Publication date: August 2020Source: Cancer Epidemiology, Volume 67Author(s): Samantha R Horn, Kelsey C Stoltzfus, Eric J Lehrer, Laura A. Dawson, Leila Tchelebi, Niraj J Gusani, Navesh K Sharma, Hanbo Chen, Daniel M Trifiletti, Nicholas G Zaorsky
Thu Jun 18, 2020 14:17
Related ArticlesDelayed M50/M100 evoked response component latency in minimally verbal/nonverbal children who have autism spectrum disorder. Mol Autism. 2019;10:34 Authors: Roberts TPL, Matsuzaki J, Blaskey L, Bloy L, Edgar JC, Kim M, Ku M, Kuschner ES, Embick D Abstract Abnormal auditory neuromagnetic M50 and M100 responses, reflecting primary/secondary auditory cortex processing, have been reported in children who have autism spectrum disorder (ASD)....
Thu Jun 18, 2020 14:14
Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemiea, b, c: Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen...
Thu Jun 18, 2020 14:14
Die Allergologie stellt sich auf Covid-19 ein. Allergo J. 2020;29(4):3 Authors: Klimek L, Jakob T PMID: 32546897 [PubMed]
Thu Jun 18, 2020 14:14
Related ArticlesCurrent ex Vivo and in Vitro Approaches to Uncovering Mechanisms of Neurological Dysfunction after Traumatic Brain Injury. Curr Opin Biomed Eng. 2020 Jun;14:18-24 Authors: Hamilton KA, Santhakumar V Abstract Traumatic brain injury often leads to progressive alterations at the molecular to circuit levels resulting in epilepsy and memory impairments. Ex vivo and in vitro models have provided a powerful platform for investigating the multimodal...
Thu Jun 18, 2020 14:14
Related ArticlesIntranasal Delivery of miR-155-5p Antagomir Alleviates Acute Seizures Likely by Inhibiting Hippocampal Inflammation. Neuropsychiatr Dis Treat. 2020;16:1295-1307 Authors: Zhou X, Chen J, Tao H, Cai Y, Huang L, Zhou H, Chen Y, Cui L, Zhong W, Li K Abstract Introduction: To confront the resistance to existing antiepileptic drugs, studies have gradually begun to investigate alternative pathologies distinct from the traditional treatments...
Thu Jun 18, 2020 14:14
Related ArticlesMicroRNAs as regulators of brain function and targets for treatment of epilepsy. Nat Rev Neurol. 2020 Jun 16;: Authors: Brennan GP, Henshall DC Abstract Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the primary clinical symptom of the epilepsies. Brain tissue from animal models and patients with acquired forms of epilepsy commonly features selective neuronal loss, gliosis, inflammatory markers...
Thu Jun 18, 2020 14:14
Related ArticlesSETD1B-associated neurodevelopmental disorder. J Med Genet. 2020 Jun 16;: Authors: Roston A, Evans D, Gill H, McKinnon M, Isidor B, Cogné B, Mwenifumbo J, van Karnebeek C, An J, Jones SJM, Farrer M, Demos M, Connolly M, Gibson WT, CAUSES Study, EPGEN Study Abstract BACKGROUND: Dysfunction of histone methyltransferases and chromatin modifiers has been implicated in complex neurodevelopmental syndromes and cancers. SETD1B encodes a lysine-specific...
Thu Jun 18, 2020 14:14
Related ArticlesThe Clinical Research Landscape of Pediatric Drug-Resistant Epilepsy. J Child Neurol. 2020 Jun 16;:883073820931255 Authors: Kaal KJ, Aguiar M, Harrison M, McDonald PJ, Illes J Abstract OBJECTIVE: To characterize the clinical research landscape of pediatric drug-resistant epilepsy (DRE) with a focus on neurotechnology. METHOD: We searched the ClinicalTrials.gov registry using the terms "epilepsy" and "drug resistant" for studies...
Thu Jun 18, 2020 14:14
Related ArticlesRevisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau. Biology (Basel). 2020 Jun 12;9(6): Authors: Paudel YN, Angelopoulou E, Piperi C, Othman I, Shaikh MF Abstract Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic...
Thu Jun 18, 2020 14:14
Related Articles[Violence and aggression in hospitals-what if the personnel need help?] Unfallchirurg. 2020 Jun;123(6):424-434 Authors: Hüfner A, Dudeck M, Zellner J, Mahr D Abstract In view of the increasing violence and aggression against medical personnel in healthcare facilities, there are considerations by the legislature to punish violent offenders in hospitals more severely. Hospital and emergency room staff are increasingly confronted by physically...
Thu Jun 18, 2020 14:14
Related ArticlesAnalysis of gene variants in the GASH/Sal model of epilepsy. PLoS One. 2020;15(3):e0229953 Authors: Díaz-Casado E, Gómez-Nieto R, de Pereda JM, Muñoz LJ, Jara-Acevedo M, López DE Abstract Epilepsy is a complex neurological disorder characterized by sudden and recurrent seizures, which are caused by various factors, including genetic abnormalities. Several animal models of epilepsy mimic the different symptoms of this disorder. In particular,...
Thu Jun 18, 2020 14:14
Related ArticlesNeuronavigation in the Identification and Presurgical Planning of Cortical Focal Dysplasia. AJNR Am J Neuroradiol. 2020 03;41(3):E10-E11 Authors: Valencia-Calderón CJ PMID: 32165358 [PubMed - indexed for MEDLINE]
Thu Jun 18, 2020 14:14
Related ArticlesPharmacological Treatments for Fragile X Syndrome Based on Synaptic Dysfunction. Curr Pharm Des. 2019;25(41):4394-4404 Authors: Telias M Abstract BACKGROUND: Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive impairment, including intellectual disability, autism, hyperactivity, and epilepsy. METHODS: This article reviews the literature pertaining to the role of synaptic dysfunction in FXS. ...
Thu Jun 18, 2020 14:14
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