Cancers, Vol. 12, Pages 1612: Phase I Radiation Dose-Escalation Study to Investigate the Dose-Limiting Toxicity of Concurrent Intra-Arterial Chemotherapy for Unresectable Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12061612 Authors: Yeona Cho Jun Won Kim Ja Kyung Kim Kwan Sik Lee Jung Il Lee Hyun Woong Lee Kwang-Hun Lee Seung-Moon Joo Jin Hong Lim Ik Jae Lee Concurrent intra-arterial chemotherapy and radiotherapy (iA-CCRT) can increase the response...
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1617: Ubiquitylation-Mediated Fine-Tuning of DNA Double-Strand Break Repair Cancers doi: 10.3390/cancers12061617 Authors: Barbara N. Borsos Hajnalka Majoros Tibor Pankotai The proper function of DNA repair is indispensable for eukaryotic cells since accumulation of DNA damages leads to genome instability and is a major cause of oncogenesis. Ubiquitylation and deubiquitylation play a pivotal role in the precise regulation of DNA repair pathways by coordinating...
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1615: Immunotherapies and Metastatic Cancers: Understanding Utility and Predictivity of Human Immune Cell Engrafted Mice in Preclinical Drug Development Cancers doi: 10.3390/cancers12061615 Authors: Kähkönen Halleen Bernoulli Metastases cause high mortality in several cancers and immunotherapies are expected to be effective in the prevention and treatment of metastatic disease. However, only a minority of patients benefit from immunotherapies. This creates...
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1613: The Quality of Practice Guidelines for Melanoma: A Methodologic Appraisal with the AGREE II and AGREE-REX Instruments Cancers doi: 10.3390/cancers12061613 Authors: Theresa Steeb Anja Wessely Konstantin Drexler Martin Salzmann Frédéric Toussaint Lucie Heinzerling Markus Reinholz Carola Berking Markus V. Heppt Multiple guidelines on cutaneous melanoma (CM) are available from several consortia and countries. To provide up-to-date guidance...
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1616: How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH Cancers doi: 10.3390/cancers12061616 Authors: Shen-Han Lee John R. Griffiths The acidic tumour microenvironment is now recognized as a tumour phenotype that drives cancer somatic evolution and disease progression, causing cancer cells to become more invasive and to metastasise. This property of solid tumours reflects a complex interplay between...
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1614: ZEB1/miR-200c/AGR2: A New Regulatory Loop Modulating the Epithelial-Mesenchymal Transition in Lung Adenocarcinomas Cancers doi: 10.3390/cancers12061614 Authors: Lucia Sommerova Eva Ondrouskova Andrea Martisova Vassilis Zoumpourlis Sotirios Galtsidis Roman Hrstka Epithelial-mesenchymal transition (EMT) is a process involved not only in morphogenesis and embryonic development, but also in cancer progression, whereby tumor cells obtain a more...
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1610: The Antihistamine Deptropine Induces Hepatoma Cell Death through Blocking Autophagosome-Lysosome Fusion Cancers doi: 10.3390/cancers12061610 Authors: Yu-Chih Liang Chi-Ching Chang Ming-Thau Sheu Shyr-Yi Lin Chia-Chen Chung Chang-Ting Teng Fat-Moon Suk Some antihistamines have exhibited significant antitumor activity alone or in combination with other therapies in in vitro and clinical studies. However, the underlying mechanisms of how antihistamines...
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1611: Positive Feedback Loop of SNAIL-IL-6 Mediates Myofibroblastic Differentiation Activity in Precancerous Oral Submucous Fibrosis Cancers doi: 10.3390/cancers12061611 Authors: Chih-Yu Peng Yi-Wen Liao Ming-Yi Lu Chieh-Mei Yang Pei-Ling Hsieh Cheng-Chia Yu Oral submucosal fibrosis (OSF) is a premalignant disorder of the oral cavity, and areca nut chewing is known to be a major etiological factor that could induce epithelial to mesenchymal transition...
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1609: Nanomedicine in Non-Small Cell Lung Cancer: From Conventional Treatments to Immunotherapy Cancers doi: 10.3390/cancers12061609 Authors: Coral García-Fernández Cristina Fornaguera Salvador Borrós Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related mortality. The heterogeneous nature of this disease hinders its diagnosis and treatment, requiring continuous advances in research aiming to understand its intricate nature....
Thu Jun 18, 2020 03:00
Cancers, Vol. 12, Pages 1608: Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model Cancers doi: 10.3390/cancers12061608 Authors: Szu-Yuan Wu Wan-Yu Yang Chun-Chia Cheng Ming-Chen Hsiao Shin-Lin Tsai Hua-Kuo Lin Kuan-Hao Lin Chiou-Hwa Yuh Radiotherapy often causes unwanted side effects such as radiation-induced fibrosis and second malignancies. Fucoidan, a sulfated polysaccharide extracted from brown seaweed,...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1488: Rab27a Contributes to the Processing of Inflammatory Pain in Mice Cells doi: 10.3390/cells9061488 Authors: Tilman Gross Gesine Wack Katharina M. J. Syhr Tanya Tolmachova Miguel C. Seabra Gerd Geisslinger Ellen Niederberger Achim Schmidtko Wiebke Kallenborn-Gerhardt Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1492: Development of Cellular Models to Study Efficiency and Safety of Gene Edition by Homologous Directed Recombination Using the CRISPR/Cas9 System Cells doi: 10.3390/cells9061492 Authors: Sabina Sánchez-Hernández Araceli Aguilar-González Beatriz Guijarro-Albaladejo Noelia Maldonado-Pérez Iris Ramos-Hernández Marina Cortijo-Gutiérrez Rosario María Sánchez Martín Karim Benabdellah Francisco Martin In spite of the enormous potential of CRISPR/Cas...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1490: PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility Cells doi: 10.3390/cells9061490 Authors: Hsin-Wei Jen De-Leung Gu Yaw-Dong Lang Yuh-Shan Jou Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients. However, the detail molecular mechanisms to facilitate cancer cell migration remain elusive. Here, we conducted integrated...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1491: Conserved Small Nucleotidic Elements at the Origin of Concerted piRNA Biogenesis from Genes and lncRNAs Cells doi: 10.3390/cells9061491 Authors: Silke Jensen Emilie Brasset Elise Parey Hugues Roest Crollius Igor V. Sharakhov Chantal Vaury PIWI-interacting RNAs (piRNAs) target transcripts by sequence complementarity serving as guides for RNA slicing in animal germ cells. The piRNA pathway is increasingly recognized as critical for essential cellular...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1493: Unilateral Cleavage Furrows in Multinucleate Cells Cells doi: 10.3390/cells9061493 Authors: Julia Bindl Eszter Sarolta Molnar Mary Ecke Jana Prassler Annette Müller-Taubenberger Günther Gerisch Multinucleate cells can be produced in Dictyostelium by electric pulse-induced fusion. In these cells, unilateral cleavage furrows are formed at spaces between areas that are controlled by aster microtubules. A peculiarity of unilateral cleavage furrows...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1486: Hepatitis B Virus Entry into Cells Cells doi: 10.3390/cells9061486 Authors: Charline Herrscher Philippe Roingeard Emmanuelle Blanchard Hepatitis B virus (HBV), an enveloped partially double-stranded DNA virus, is a widespread human pathogen responsible for more than 250 million chronic infections worldwide. Current therapeutic strategies cannot eradicate HBV due to the persistence of the viral genome in a special DNA structure (covalently closed circular...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1485: Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy Cells doi: 10.3390/cells9061485 Authors: Jan A. Rath Caroline Arber T cell receptor (TCR)-based adoptive T cell therapies (ACT) hold great promise for the treatment of cancer, as TCRs can cover a broad range of target antigens. Here we summarize basic, translational and clinical results that provide insight into the challenges and opportunities of TCR-based ACT. We review the characteristics...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1487: A Cellular Automaton Model as a First Model-Based Assessment of Interacting Mechanisms for Insulin Granule Transport in Beta Cells Cells doi: 10.3390/cells9061487 Authors: Müller Glombek Powitz Brüning Rustenbeck In this paper a first model is derived and applied which describes the transport of insulin granules through the cell interior and at the membrane of a beta cell. A special role is assigned to the actin network, which significantly...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1484: Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL Cells doi: 10.3390/cells9061484 Authors: Rainer Hubmann Susanne Schnabl Mohammad Araghi Christian Schmidl André F. Rendeiro Martin Hilgarth Dita Demirtas Farghaly Ali Philipp B. Staber Peter Valent Christoph Zielinski Ulrich Jäger Medhat Shehata NOTCH signaling represents a promising therapeutic target in chronic lymphocytic leukemia...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1489: Development and Differentiation of Midbrain Dopaminergic Neuron: From Bench to Bedside Cells doi: 10.3390/cells9061489 Authors: Mengmeng Wang King-Hwa Ling Jun Jie Tan Cheng-Biao Lu Parkinson’s Disease (PD) is a neurodegenerative disorder affecting the motor system. It is primarily due to substantial loss of midbrain dopamine (mDA) neurons in the substantia nigra pars compacta and to decreased innervation to the striatum. Although existing...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1483: CDK12: A Potent Target and Biomarker for Human Cancer Therapy Cells doi: 10.3390/cells9061483 Authors: Shujing Liang Lifang Hu Zixiang Wu Zhihao Chen Shuyu Liu Xia Xu Airong Qian Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It...
Thu Jun 18, 2020 03:00
Cells, Vol. 9, Pages 1482: A Microfluidic Single-Cell Cloning (SCC) Device for the Generation of Monoclonal Cells Cells doi: 10.3390/cells9061482 Authors: Chuan-Feng Yeh Ching-Hui Lin Hao-Chen Chang Chia-Yu Tang Pei-Tzu Lai Chia-Hsien Hsu Single-cell cloning (SCC) is a critical step in generating monoclonal cell lines, which are widely used as in vitro models and for producing proteins with high reproducibility for research and the production of therapeutic drugs. In monoclonal...
Thu Jun 18, 2020 03:00
Challenges, Vol. 11, Pages 11: Sustainable Distribution of Responsibility for Climate Change Adaptation Challenges doi: 10.3390/challe11010011 Authors: Åsa Knaggård Erik Persson Kerstin Eriksson To gain legitimacy for climate change adaptation decisions, the distribution of responsibility for these decisions and their implementation needs to be grounded in theories of just distribution and what those affected by decisions see as just. The purpose of this project is to contribute...
Thu Jun 18, 2020 03:00
Chemosensors, Vol. 8, Pages 41: Voltammetric Sensors Based on Nanomaterials for Detection of Caffeic Acid in Food Supplements Chemosensors doi: 10.3390/chemosensors8020041 Authors: Alexandra Virginia Bounegru Constantin Apetrei Caffeic acid may be accurately detected in food supplements by using cyclic voltammetry and carbon screen-printed sensors modified with various nanomaterials. Sensor characterization by cyclic voltammetry in reference solutions has shown that carbon nanotubes...
Thu Jun 18, 2020 03:00
Chemosensors, Vol. 8, Pages 40: Investigation of Rapid Gas-Sensitive Properties Degradation of ZnO–SnO2 Thin Films Grown on the Glass Substrate Chemosensors doi: 10.3390/chemosensors8020040 Authors: Victor V. Petrov Ekaterina M. Bayan Soslan A. Khubezhov Yuri N. Varzarev Maria G. Volkova ZnO–SnO2 films with a thickness of up to 120 nm have been prepared on glass substrates by pyrolysis at 550 °C of three spin-coated organic precursors films. Films of four...
Thu Jun 18, 2020 03:00
Children, Vol. 7, Pages 64: Effect of Action Observation Training on Spasticity, Gross Motor Function, and Balance in Children with Diplegia Cerebral Palsy Children doi: 10.3390/children7060064 Authors: Young-a Jeong Byoung-Hee Lee This study evaluated the effect of action observation training on spasticity, gross motor function, and balance in children with spastic diplegia cerebral palsy. Eighteen children with cerebral palsy participated in this study. The participants were randomized...
Thu Jun 18, 2020 03:00
Dentistry Journal, Vol. 8, Pages 59: Oral and Dental Abnormalities Caused by a Pediatric Rhabdomyosarcoma Tumor Treatment: A Clinical Case Report Dentistry Journal doi: 10.3390/dj8020059 Authors: Luísa Bandeira Lopes Rodrigo Themudo João Botelho Vanessa Machado Rhabdomyosarcoma is one of the most common soft-tissue sarcomas in children. The therapy for this condition has evolved significantly over recent decades, as has survival rates. Nevertheless, multiagent chemotherapy,...
Thu Jun 18, 2020 03:00
Diagnostics, Vol. 10, Pages 415: Comparison between Statistical Models and Machine Learning Methods on Classification for Highly Imbalanced Multiclass Kidney Data Diagnostics doi: 10.3390/diagnostics10060415 Authors: Bomi Jeong Hyunjeong Cho Jieun Kim Soon Kil Kwon SeungWoo Hong ChangSik Lee TaeYeon Kim Man Sik Park Seoksu Hong Tae-Young Heo This study aims to compare the classification performance of statistical models on highly imbalanced kidney data. The...
Thu Jun 18, 2020 03:00
Diagnostics, Vol. 10, Pages 414: The Suitability of FGF21 and FGF23 as New Biomarkers in Endometrial Cancer Patients Diagnostics doi: 10.3390/diagnostics10060414 Authors: Aneta Cymbaluk-Płoska Paula Gargulińska Anita Chudecka-Głaz Sebastian Kwiatkowski Ewa Pius-Sadowska Bogusław Machaliński Endometrial cancer is one of the most common cancers of the reproductive organ in women. The incidence of it increases from year to year. In our study we assessed role of FGF21 and...
Thu Jun 18, 2020 03:00
EJIHPE, Vol. 10, Pages 669-681: Concrete Messages Increase Healthy Eating Preferences European Journal of Investigation in Health, Psychology and Education doi: 10.3390/ejihpe10020049 Authors: Emily Balcetis Madhumitha Manivannan E. Blair Cox Public health campaigns utilize messaging to encourage healthy eating. The present experimental study investigated the impact of three components of health messages on preferences for healthy foods. We exposed 1676 online, American study participants...
Thu Jun 18, 2020 03:00
Fermentation, Vol. 6, Pages 61: Evaluation of Media Components and Process Parameters in a Sensitive and Robust Fed-Batch Syngas Fermentation System with Clostridium ljungdahlii Fermentation doi: 10.3390/fermentation6020061 Authors: Infantes Kugel Neumann The fermentation of synthesis gas, or syngas, by acetogenic bacteria can help in transitioning from a fossil-fuel-based to a renewable bioeconomy. The main fermentation products of Clostridium ljungdahlii, one of such microorganisms,...
Thu Jun 18, 2020 03:00
Foods, Vol. 9, Pages 805: Wine Quality Drivers: A Case Study on South African Chenin Blanc and Pinotage Wines Foods doi: 10.3390/foods9060805 Authors: Brand Panzeri Buica The aim of the study was to propose a methodology for the elucidation of sensory and chemical wine quality drivers. The winners of the 2018 Top 10 Chenin Blanc and Top 10 Pinotage challenges and additional lower scoring wines for each cultivar were evaluated. The two sets underwent sensory profiling by Check-All-That-Apply...
Thu Jun 18, 2020 03:00
Foods, Vol. 9, Pages 801: Rapid Pasteurization of Apple Juice Using a New Ultrasonic Reactor Foods doi: 10.3390/foods9060801 Authors: Baboli Williams Chen A new ultrasonic reactor was used to rapidly inactivate Escherichia coli and Staphylococcus aureus in apple juice. It was found that high pulp content made ultrasound less lethal to S. aureus, while it had no significant effect on E. coli. When the pulp free apple juice was ultrasonically processed, the 5-log reduction time...
Thu Jun 18, 2020 03:00
Foods, Vol. 9, Pages 803: Quality and Safety of Meat Products Foods doi: 10.3390/foods9060803 Authors: Begoña Panea Guillermo Ripoll Food safety is a major problem around the world, both regarding human suffering and with respect to economic costs. Scientific advances have increased our knowledge surrounding the nutritional characteristics of foods and their effects on health. This means that a large proportion of consumers are much more conscious with respect to what they eat and...
Thu Jun 18, 2020 03:00
Foods, Vol. 9, Pages 802: Impact of the Timing and Temperature of Malolactic Fermentation on the Aroma Composition and Mouthfeel Properties of Chardonnay Wine Foods doi: 10.3390/foods9060802 Authors: Sereni Phan Osborne Tomasino Malolactic fermentation (MLF) is an important process in wine production due to the resulting reduction in acidity. MLF is typically induced by the addition of Oenococcus oeni after the completion of alcoholic fermentation (AF), but can occur concurrent...
Thu Jun 18, 2020 03:00
Foods, Vol. 9, Pages 804: Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage Foods doi: 10.3390/foods9060804 Authors: Taamalli Feriani Lozano-Sanchez Ghazouani El Mufti Allagui Segura-Carretero Mhamdi Arráez-Roman Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the...
Thu Jun 18, 2020 03:00
Foods, Vol. 9, Pages 800: Chemistry and Sensory Characterization of a Bakery Product Prepared with Oils from African Edible Insects Foods doi: 10.3390/foods9060800 Authors: Xavier Cheseto Steve B.S. Baleba Chrysantus M. Tanga Segenet Kelemu Baldwyn Torto Globally, there is growing interest to integrate insect-derived ingredients into food products. Knowledge of consumer perception to these food products is growing rapidly in the literature, but similar knowledge on the use...
Thu Jun 18, 2020 03:00
Geriatrics, Vol. 5, Pages 38: Effect of Self-Management Support for Elderly People Post-Stroke: A Systematic Review Geriatrics doi: 10.3390/geriatrics5020038 Authors: Sedsel Kristine Stage Pedersen Susanne Lillelund Sørensen Henriette Holm Stabel Iris Brunner Hanne Pallesen A systematic review was undertaken to determine the efficacy of self-management interventions for people with stroke over the age of 65 in relation to psychosocial outcomes. PubMed, Embase, and PsycInfo...
Thu Jun 18, 2020 03:00
Heritage, Vol. 3, Pages 474-491: Partaking in Culinary Heritage at Yaxunah, Yucatán during the 2017 Noma Mexico Pop-Up Heritage doi: 10.3390/heritage3020028 Authors: Fisher Ardren In spring of 2017, celebrity chef René Redzepi opened a pop-up of his famed restaurant, Noma, on the coast of the Yucatán Peninsula. During its run, Noma Mexico worked closely with the town of Yaxunah, a Yucatec-Mayan speaking community in the peninsula’s interior, hiring...
Thu Jun 18, 2020 03:00
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