Purpose: Assess safety and efficacy of nivolumab plus nab-paclitaxel and gemcitabine in patients with locally advanced/metastatic pancreatic cancer in a 2-part, open-label, phase 1 trial. Experimental Design: Fifty chemotherapy-naive patients received nab-paclitaxel 125 mg/m2 plus gemcitabine 1000 mg/m2 (days 1, 8, and 15) and nivolumab 3 mg/kg (days 1 and 15) in 28-day cycles. The primary endpoints were dose-limiting toxicities (DLTs; part 1) and grade 3/4 treatment-emergent adverse events (TEAEs)...
Thu Jun 18, 2020 16:42
Purpose: Anti-programmed cell death protein 1 (PD-1) therapy has demonstrated inconsistent therapeutic results in patients with glioblastoma (GBM) including those with profound impairments in CD8 T cell effector responses Experimental Design: . We observed a survival benefit in immunocompetent mice with endogenously-arising intracranial glioblastomas after intravenous administration of anti-PD-1. The therapeutic effect of PD-1 administration persisted in mice even after genetic ablation of the CD8...
Thu Jun 18, 2020 16:42
We investigated the effectiveness of mate allocation strategies accounting for non-additive genetic effects to improve crossbred performance in a two-way crossbreeding scheme. We did this by computer simulation of 10 generations of evaluation and selection. QTL effects were simulated as correlated across purebreds and crossbreds, and (positive) heterosis was simulated as directional dominance. The purebred-crossbred correlation was 0.30 or 0.68 depending on the genetic variance component used. Dominance...
Thu Jun 18, 2020 22:56
Abstract Purpose Various procedures have been adopted for eminence augmentation for treatment of recurrent temporomandibular joint dislocation. The aim of this study is to assess maximal incisal opening (MIO) using a custom-made titanium implant versus inlay autogenous augmentation from the patient’s chin for more stable condylar movements. Methods ...
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Abstract Purpose The coronectomy technique is an alternative to conventional impacted tooth removal which aims to reduce the risk of damage to the inferior alveolar nerve (IAN). The technique is usually performed by senior oral surgeons or residents in training. Herein, patients were treated in a single service, in which coronectomy was performed by an undergraduate dental student on partially erupted lower third molars. ...
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British Journal of Cancer, Published online: 19 June 2020; doi:10.1038/s41416-020-0938-zDistinct temporal trends in breast cancer incidence from 1997 to 2016 by molecular subtypes: a population-based study of Scottish cancer registry data
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Conditions: Nasopharyngeal Carcinoma; Nutrition TherapyInterventions: Other: Standardized nutrition therapy; Drug: Cisplatin; Radiation: Intensity Modulated Radiation TherapySponsors: Sun Yat-sen University; Wuhan University; The First Affiliated Hospital of Xiamen University; Fudan University; Jiangxi Provincial Cancer Hospital; Xijing Hospital; Xiangya Hospital of Central South University; Fujian Cancer Hospital; Zhejiang Cancer Hospital; Cancer Hospital of Guizhou ProvinceRecruiting
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Condition: Advanced Esophageal Squamous Cell CancerIntervention: Drug: tpripalimabSponsor: RenJi HospitalRecruiting
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Condition: Nasopharyngeal CarcinomaInterventions: Drug: Docetaxel, nedaplatin, fluorouracil; Drug: Docetaxel, cisplatin, fluorouracil; Drug: Nedaplatin; Drug: Cisplatin; Radiation: Intensity modulated-radiotherapySponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityRecruiting
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Condition: Head and Neck CancerIntervention: Device: MSOT Acuity Echo deviceSponsor: University Hospital HeidelbergNot yet recruiting
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Rejuvenation Research, Volume 23, Issue 3, Page 245-255, June 2020.
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Rejuvenation Research, Volume 23, Issue 3, Page 274-279, June 2020.
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Rejuvenation Research, Volume 23, Issue 3, Page 262-265, June 2020.
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Rejuvenation Research, Volume 23, Issue 3, Page 237-244, June 2020.
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Rejuvenation Research, Volume 23, Issue 3, Page 191-192, June 2020.
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Rejuvenation Research, Volume 23, Issue 3, Page 224-236, June 2020.
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Rejuvenation Research, Volume 23, Issue 3, Page 266-273, June 2020.
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Rejuvenation Research, Volume 23, Issue 3, Page 256-261, June 2020.
Tue Jun 16, 2020 10:00
Abstract Purpose To determine the factors that sleep medicine/surgery fellowship program directors look for in applicants. Methods Program directors from 9 sleep medicine/surgery fellowship programs in the USA were sent an anonymous online survey. They were asked to select the five most important academic factors (of a list of 17) when evaluating potential...
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Understanding the emergence of novel viruses requires an accurate and comprehensive annotation of their genomes. Overlapping genes (OLGs) are common in viruses and have been associated with the origins of pandemics, but are still widely overlooked. We identify ORF3c, a novel OLG in SARS-CoV-2 that is also present in Guangxi pangolin-CoVs but not more closely related pangolin-CoVs (Guangdong) or bat-CoVs (RaTG13 and RmYN02). We then document evidence of translation from ribosome profiling and conduct...
Thu Jun 18, 2020 03:00
Despite all efforts to control the COVID-19 spread, the SARS-CoV-2 reached South America within three months after its first detection in China, and Brazil became one of the hotspots of COVID-19 in the world. Several SARS-CoV-2 lineages have been identified and some local clusters have been described in this early pandemic phase in Western countries. Here we investigated the genetic diversity of SARS-CoV-2 during the early phase (late February to late April) of the epidemic in Brazil. Phylogenetic...
Thu Jun 18, 2020 03:00
Entering and exiting winter dormancy presents important trade-offs between growth and survival at northern latitudes and many forest trees display local adaptation across latitude. Transfers of a species outside its native range introduce the species to novel combinations of environmental conditions potentially requiring different combinations of alleles to optimize growth. We performed genome-wide association analyses and a selection scan in a P. trichocarpa mapping population derived from crossings...
Thu Jun 18, 2020 03:00
The ecological and evolutionary factors underlying life history trait variation is one of the most interesting topics in biology. Although many studies have evaluated either macroevolutionary or macroecological patterns of life history traits across several taxonomic groups, only few studies have attempted to integrate both dimensions in a single analytical framework. Here, we study how parity mode evolved across multiple scales in the radiation of spiny lizards (Squamata: Phrynosomatidae). We adopted...
Thu Jun 18, 2020 03:00
Environmental seasonality is a potent evolutionary force, capable to maintain polymorphism, promote phenotypic plasticity, and cause bet-hedging. In Drosophila, it has been reported to affect life-history traits, tolerance to abiotic stressors, and immunity. Oscillations in frequencies of alleles underlying fitness-related traits were also documented alongside SNP alleles across genome. Here, we test for seasonal changes in recombination in a natural D. melanogaster population from India using morphological...
Thu Jun 18, 2020 03:00
A successful biological invasion involves survival in a newly occupied environment. If a population bottleneck occurs during an invasion, the resulting depletion of genetic variants could cause increased inbreeding depression and decreased adaptive potential, which may result in a fitness reduction. How invasive populations survive in the newly occupied environment despite reduced heterozygosity and how, in many cases, they maintain moderate levels of heterozygosity are still contentious issues....
Thu Jun 18, 2020 03:00
Statistical phylogenetic analysis currently relies on complex, dedicated software packages, making it difficult for evolutionary biologists to explore new models and inference strategies. Recent years have seen more generic solutions based on probabilistic graphical models, but this formalism can only partly express phylogenetic problems. Here we show that universal probabilistic programming languages (PPLs) solve the model expression problem, while still supporting automated generation of efficient...
Thu Jun 18, 2020 03:00
Some sea slug species sequester chloroplasts from algal food in their digestive gland cells and photosynthesize for up to several months. This phenomenon, kleptoplasty, poses a question of how the chloroplast retains its activity within the animal cell without the algal nucleus. As a mechanism of the retention, there have been debates on horizontal gene transfer from the algal nucleus to animal nucleus. To settle the arguments, we, here, report the genome of a kleptoplastic sea slug Plakobranchus...
Thu Jun 18, 2020 03:00
Satellite viruses are hyper-parasites that can alter the virulence and transmissibility of the helper viruses they exploit. How satellites diversify given their dependence on unrelated viruses is unclear. We explored the capacity of deltaviruses, a group of animal-infecting satellites, to transmit between host species using metagenomic and field studies of bats. Among 44 bat genera from 11 countries, deltaviruses were exclusively found in common vampire bats. Phylogenetic analysis implied independent...
Thu Jun 18, 2020 03:00
Colijn & Plazzotta (Syst. Biol 67:113-126, 2018) introduced a scheme for bijectively associating the unlabeled binary rooted trees with the positive integers. First, the rank 1 is associated with the 1-leaf tree. Proceeding recursively, ordered pair (k1,k2), k1 [≥] k2 [≥] 1, is then associated with the tree whose left subtree has rank k1 and whose right subtree has rank k2. Following dictionary order on ordered pairs, the tree whose left and right subtrees have the ordered pair of ranks (k1,k2)...
Thu Jun 18, 2020 03:00
Classical evolutionary theory maintains that mutation rate variation between genes should be random with respect to fitness and evolutionary optimization of genic mutation rates remains controversial. However, it has now become known that cytogenetic (DNA sequence + epigenomic) features influence local mutation probabilities, which is predicted by more recent theory to be a prerequisite for beneficial mutation rates between different classes of genes to readily evolve. To test this possibility, we...
Thu Jun 18, 2020 03:00
Effective communication in birds is often hampered by background noise, with many recent studies focusing on the effect of anthropogenic noise on passerine bird song. Continuous low-frequency natural noise is predicted to drive changes in both frequency and temporal patterning of bird vocalizations, but the extent to which these effects may also affect birds that lack vocal learning is not yet fully understood. Here we use a gradient of exposure to natural low-frequency noise to assess whether it...
Thu Jun 18, 2020 03:00
Summary Exon 18 mutations account for only 3.6% of EGFR mutations, and tumors with exon 18 mutations are often unresponsive to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We present a novel case of a lung adenocarcinoma with an exon 18 mutation resulting in a glycine to serine substitution at position 719 of the EGFR protein. The patient received osimertinib, a third generation EGFR-TKI, as the first-line treatment, but the disease progressed during...
Thu Jun 18, 2020 03:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1163-7230Gastroparesis is an important complication of diabetes. Motility disorders are underdiagnosed and can lead to unexplained hypoglycemia. Currently diagnostic options are limited. All established methods harbor certain disadvantages. The 3D-MAGMA system is capable of reliably measuring gastric and small intestinal motility. The aim of the current study was to determine...
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 351-352DOI: 10.1055/a-1134-6013© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 354-355DOI: 10.1055/a-1134-3011© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 348-349DOI: 10.1055/a-1095-2498© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 352-354DOI: 10.1055/a-0996-6623© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 374-376DOI: 10.1055/a-1095-2619© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 377-390DOI: 10.1055/a-1076-9742Das Behçet-Syndrom gehört zu den Vaskulitiden variabler Gefäßgröße. Das klinische Bild ist sehr vielfältig und erfordert in der Regel eine interdisziplinäre Zusammenarbeit. Pathogenetisch scheint es eine Mittelstellung zwischen einer polygenetischen Autoinflammationserkrankung und einer autoimmunen Erkrankung einzunehmen. 2018 wurden neue EULAR-Empfehlungen herausgegeben. Die Therapie richtet sich nach der führenden Beteiligung der einzelnen...
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 412-413DOI: 10.1055/a-1095-2641© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 414-430DOI: 10.1055/a-0956-8339Due to cholesteatoma's slowly progressive and destructive growth there is a risk of intracranial and potentially life-threatening complications. That's why every cholesteatoma is a basically absolute indication for surgery. Only asymptomatic and small retractions, so-called prae-cholesteatomas, may be under observation. While the first part of this article focused on the basics of pathogenesis and diagnostics, this one provides an overview...
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 431-432DOI: 10.1055/a-1095-2663© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 18, 2020 02:00
Laryngorhinootologie 2020; 99: 433-434DOI: 10.1055/a-1095-2674© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Thu Jun 18, 2020 02:00
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