Abstract Acute phase reactants (APR) are proteins that had been associated with psoriasis severity. We aimed to evaluate the association between psoriasis disease severity and some inflammatory markers as (CRP, ESR and fibrinogen) before and after narrow band ultraviolet NB (NB‐UVB) therapy. The present study included 38 psoriatic patients and 38 controls of matching age and sex. The 38 included patients were divided according to their pre‐treatment PASI score into 2 subgroups: moderate 13 (34.2%)...
Wed Jun 17, 2020 20:12
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Wed Jun 17, 2020 19:30
COVID‐19 is a highly contagious respiratory infection caused by severe acute respiratory syndrome coronavirus 2. COVID‐19 outbreak, has been declared a pandemic by the World Health Organization on March, 2020. The pandemic has affected the management of psoriasis, not only for those who are under treatment but also for those who are about to begin a new therapy to control their disease. An increasing number of studies in the current literature have focused on the relationship between psoriasis and...
Wed Jun 17, 2020 17:43
Wed Jun 17, 2020 15:10
Abstract The newly emerged Coronavirus disease 2019 (COVID‐19) is an infectious disease that has spread rapidly throughout the world. The most common signs and symptoms are fever, dry cough and shortness of breath which can progress to severe viral pneumonia and multi‐organ failure in susceptive patients (Chen et al. 2020, Wang et al. 2020). Droplet transmission and person‐person transmission appear to be the main route of transmission of COVID‐19, however asymptomatic patients are also carriers...
Wed Jun 17, 2020 21:39
Abstract Objectives The aim of this study was to identify prognostic autophagy‐related genes and assess the ability of these genes to predict clinical outcomes in oral squamous cell carcinoma (OSCC). Subjects and Methods The details of the human autophagy‐related genes were obtained from the Human Autophagy Database. The Cancer Genome Atlas database was used to obtain the gene expression profiles and clinical data of patients. Prediction of biological functions of differentially expressed...
Wed Jun 17, 2020 18:39
Abstract The consequences of the SARS‐CoV‐2 pandemic has significantly affected dental practice. Since dental care is considered a high‐risk activity (Volgenant et al., 2020), public and private dental clinics are closed to non‐urgent cases in many countries. Several new routines and practices have been proposed to reduce this risk in dental offices, but standard dental treatment is expected to happen only after the “first wave” of disease and on an entirely new basis.
Wed Jun 17, 2020 12:42
Abstract The ability to express different phenotypes can help define species distributions by allowing access to, and exploitation of, new environments. Social insects employ two markedly different reproductive strategies with contrasting cost/benefit characteristics: independent colony foundation (ICF), which is associated with high dispersal range and high risk, and dependent colony foundation (DCF), characterized by low risk but low dispersal. The ant Myrmecina nipponica employs both of these...
Wed Jun 17, 2020 20:20
Abstract Cooperation can be favored through the green‐beard mechanism, where a set of linked genes encodes both a cooperative trait and a phenotypic marker (green beard), which allows carriers of the trait to selectively direct cooperative acts to other carriers. In theory, the green‐beard mechanism should favor cooperation even when interacting partners are totally unrelated at the genome level. Here, we explore such an extreme green‐beard scenario between two unrelated bacterial species – Pseudomonas...
Wed Jun 17, 2020 18:15
Abstract With only a few absolute geographic barriers in marine environments, the factors maintaining reproductive isolation among marine organisms remain elusive. However, spatial structuring in breeding habitat can contribute to reproductive isolation. This is particularly important for marine organisms that migrate to use fresh‐ or brackish water environments to breed. The Japanese Gasterosteus stickleback species, the Pacific Ocean three‐spined stickleback (G. aculeatus ) and the Japan Sea...
Wed Jun 17, 2020 12:09
ABSTRACT Biallelic loss‐of‐function mutations in the centrosomal pericentrin gene (PCNT ) cause microcephalic osteodysplastic primordial dwarfism type II (MOPDII), which is characterized by extreme growth retardation, microcephaly, skeletal dysplasia, and dental anomalies. Life expectancy is reduced due to a high risk of cerebral vascular anomalies. Here, we report two siblings with MOPDII and attenuated growth restriction, and pachygyria. Compound heterozygosity for two novel truncated PCNT...
Wed Jun 17, 2020 20:25
ABSTRACT Nucleotide Excision Repair associated diseases comprise overlapping phenotypes and a wide range of outcomes. The early stages still remain under‐investigated and underdiagnosed, even though an early recognition of the first symptoms is of utmost importance for appropriate care and genetic counselling. We systematically collected clinical and molecular data from the literature and from newly diagnosed NER patients with neurological impairment, presenting clinical symptoms before the...
Wed Jun 17, 2020 20:25
Objectives Laryngotracheal stenosis (LTS) is a fibrotic condition of the upper airway. Recent evidence suggests dysregulated host immunity plays a role in LTS development and progression. The programmed death‐1 (PD‐1)/programmed death‐ligand 1 (PD‐L1) axis, targeted by paradigm‐shifting immunotherapies for cancer treatment, has also recently been implicated in the pathogenesis of fibrotic pulmonary disease. However, a role for the PD‐1/PD‐L1 axis in the proximal airway fibrosis seen in LTS patients...
Wed Jun 17, 2020 21:54
Objectives/Hypothesis Response to upper airway stimulation (UAS) is associated with the degree of airway opening during stimulation. UAS programming may affect this opening. The objective of this study was to examine airway changes in response to five different electrode configurations programmable within the Inspire UAS system. Study Design Prospective single‐arm cohort study. Methods Subjects who underwent UAS implantation were recruited for a prospective single‐arm cohort study during...
Wed Jun 17, 2020 21:50
Volumetric Analysis of the Vocal Folds Using Computed Tomography: Effects of Age, Height, and Gender
Objective The goal of this study was to use computed tomography (CT) volumetric analysis to assess the effect of age, gender, height, body mass index (BMI), and ethnicity on vocal fold volume in patients with normal larynges. Study Design Retrospective cross‐sectional study. Methods Vocal fold length, width, and height were measured in a total of 105 patients without a history of laryngeal or thyroid pathology on thin‐section soft‐tissue neck CTs. The product of the three dimensions...
Wed Jun 17, 2020 21:34
Abstract Background Somatostatin receptors (SSTs) are widely co-expressed in pituitary tumors. SST2 and SST5 are the most represented SST subtypes. First-generation somatostatin receptor ligands (SRLs) mainly target SST2, while pasireotide, a multi-receptor ligand, shows high binding affinity for both SST5 and SST2. Therefore, SRLs are routinely used as medical treatment for GH-, TSH-, and ACTH-secreting pituitary tumors. ...
Thu Jun 18, 2020 03:00
Wed Jun 17, 2020 13:51
Abstract The eighth edition of the American Joint Committee on Cancer (AJCC8) staging manual has major changes in oral squamous cell carcinoma (OSCC). We searched PubMed, OvidMedline, Scopus, and Web of Science for studies that examined the performance of AJCC8 in OSCC. A total of 40 808 patients were included in the studies of our meta‐analysis. A hazard ratio (HR) of 1.87 (95%CI 1.78‐1.96) was seen for stage II, 2.65 (95%CI 2.51‐2.80) for stage III, 3.46 (95%CI 3.31‐3.61) for stage IVa, and 7.09...
Wed Jun 17, 2020 11:00
Abstract Background House dust mite (HDM) is a well‐known cause of asthma. Allergen specific immunotherapy (AIT) can only modify the natural course of the disease. Conventional routes of HDM AIT are subcutaneous or sublingual. Subcutaneous immunotherapy (SCIT) has a disadvantage of systemic hypersensitive reaction, and the sublingual immunotherapy has a disadvantage of local allergic reaction and low drug adherence. Objective To overcome the weak points of conventional AIT, we developed...
Wed Jun 17, 2020 12:51
Abstract Background House dust mite (HDM) sublingual immunotherapy (SLIT) has demonstrated efficacy in clinical trials of patients with asthma. Airway inflammation is a characteristics of respiratory allergy, but its relationship to SLIT remain unclear. Objective We evaluate the association between clinical outcomes with pulmonary function and biomarkers in before and after HDM SLIT (UMIN‐Number 000022390). Methods One hundred twelve patients with asthma sensitized to HDM were randomized...
Wed Jun 17, 2020 12:49
Abstract Objective To assess the diagnostic accuracy of inhalation challenge tests for bird fancier’s lung and related adverse reactions. Design We performed a systematic review and meta‐analysis for the diagnostic test accuracy of inhalation challenge tests and a systematic review for adverse events of the tests. We evaluated the risk of bias and applicability of the included articles for diagnostic test accuracy with the modified Quality Assessment of Diagnostic Accuracy Studies‐2 tool....
Wed Jun 17, 2020 12:43
The bioorthogonal inverse‐electron‐demand Diels–Alder (IEDDA) cleavage reaction between tetrazine and trans‐cyclooctene (TCO) is a powerful way to control the release of bioactive agents and imaging probes. In this study, a pretargeted activation strategy using single‐walled carbon nanotubes (SWCNTs) that bear tetrazines (TZ@SWCNTs) and a TCO‐caged molecule was used to deliver active effector molecules. To optimize a turn‐on signal by using in vivo fluorescence imaging, we developed a new fluorogenic...
Thu Jun 18, 2020 10:39
A blinking mesoporous TiO2−x is composed of small, crystalline, vacancy‐rich anatase nanoparticles. It shows unique optical, thermal, electronic, and photocatalytic properties. The nanoparticles continuously light up and fade away for an extended period of time under an electron beam. They also show long‐lived charge carriers (trapped electrons and holes) at room temperature in the dark, even long (30 min) after UV irradiation. Abstract A mesoporous TiO2−x material comprised of small,...
Wed Jun 17, 2020 22:00
We report an oxidative ring‐opening strategy to transform cyclopropylamides and cyclobutylamides into fluorinated imines. The imines can be isolated in their more stable hemiaminal form, with the fluorine atom installed selectively at the g or d position. Both cheap benzophenone with UV A light or organic and inorganic dyes with blue light could be used as photoredox catalysts to promote this process. Various fluorinated amines were then obtained by nucleophilic attack on the hemiaminals in one pot,...
Wed Jun 17, 2020 21:30
The first iridium catalyzed, enantioconvergent amination of allenylic carbonates is reported. This process utilizes various commercially available carbamates and sulfonamides to generate allenylic amines including commonly employed protected groups (Boc, Fmoc, Cbz, Ts, Ns) in 62‐82% yield and 87‐98% ee. The products generated via this scalable procedure serve as effective linchpins for the rapid, enantiospecific synthesis of a wide range of complex structures.
Wed Jun 17, 2020 21:29
Upconversion photoluminescence in heterooligonuclear metal complex architectures featuring organic ligands is an interesting but still rarely observed phenomenon, despite its great potential from a basic research and application perspective. In this context, a new photonic material consisting of molecular chromium(III) and ytterbium(III) complex ions was developed that exhibits excitation power density‐dependent cooperative sensitization of the chromium‐centered 2 E/ 2 T 1 phosphorescence at...
Wed Jun 17, 2020 20:29
Not long ago, the occurrence of quantum mechanical tunneling (QMT) chemistry involving atoms heavier than hydrogen was considered unreasonable. Contributing to the shift of this paradigm, we present here the discovery of a new and distinct heavy‐atom QMT reaction. Triplet syn ‐2‐formyl‐3‐fluorophenylnitrene, generated in argon matrices by UV‐irradiation of an azide precursor, was found to spontaneously cyclize to singlet 4‐fluoro‐2,1‐benzisoxazole. Monitoring the transformation by IR spectroscopy,...
Wed Jun 17, 2020 20:25
Graphdiyne (GDY) as an emerging two‐dimensional carbon allotrope exhibits excellent performance in energy chemistry, catalytic chemistry, optoelectronics, electronics, etc. due to the unique structure combines sp‐ and sp2 hybrid carbon network. However, the poor solubility of pristine GDY is the major obstacle to its applications in many fields. Herein, we propose a facile strategy to control the preparation of graphdiyne quantum dots (GDY‐Py QDs), in which pyrene groups are covalently linked to...
Wed Jun 17, 2020 18:59
This review examines the intermarriage of perovskite and metal‐organic framework crystals as bringing new paradigms for material design and functionality. The strategic combination of halide perovskites and metal‐organic frameworks (MOFs) crystals has generated a new family of porous composite materials that will enable new applications including optoelectronic, catalysis, sensing, and data encryption. This review surveys the current progress of this exciting new area. The fundamental aspects, including...
Wed Jun 17, 2020 18:29
Little is known about the pathway of room‐temperature formation of ternary CdTeSe magic‐size clusters (MSCs) obtained via mixing binary CdTe and CdSe induction period samples containing binary precursor compounds (PCs) of MSCs, monomers (Ms), and fragments (Fs). Also, unestablished are dispersion effects that occur when as‐mixed samples (without incubation) are placed in toluene (Tol) and octylamine (OTA) mixtures. The resulting ternary MSCs, exhibiting sharp optical absorption peaking at 399 nm,...
Wed Jun 17, 2020 17:46
The life‐inspired dynamic behaviours of emulsions are receiving increasing attention from wide scientific communities, however, the spatiotemporal control and functionalization of emulsions based on simple fusion‐induced method is rarely mentioned. Here, we design protein‐stabilized oil‐in‐water droplets and phospholipid‐stabilized oil‐in‐water droplets, and propose a substance‐diffusion mediated fusion mechanism within these two different emulsion communities. Significantly, a range of fusion‐induced...
Wed Jun 17, 2020 17:43
Distance‐dependent electromagnetic radiation and electron transfer have been commonly employed in washing‐free fluorescence and electrochemical bioassays, respectively. Here, we combine the two distance‐dependent phenomena to obtain sensitive washing‐free DNA detection. Distance‐dependent surface plasmonic field induces rapid photoredox catalysis of surface‐bound catalytic labels, and distance‐dependent mediated electron transfer allows for rapid electron transfer from the surface‐bound labels to...
Wed Jun 17, 2020 14:28
A reductive approach : A diselenide‐based probe for the detection of thioredoxin reductase 1 (TrxR1) was designed and synthesized. The non‐fluorescent probe switched on in the presence of TrxR1 and had minimal interference from other biological reducing species. The diselenide probe was successfully used in imaging TrxR1 in human lung cancer cells and showed greater fluorescence compared to a disulfide‐based analogue. Abstract We report the first diselenide‐based probe for the selective detection...
Wed Jun 17, 2020 12:32
Give and take : Operando Raman spectroscopy in combination with in situ XRD and thermal analysis was applied to study a Mn‐Na2WO4/SiO2 catalyst at work during the oxidative coupling of methane. Melting of Na2WO4 and Mn7SiO12‐MnWO4 redox chemistry occur simultaneously, thereby enabling the transient release and storage of active sodium oxide species. Coupling of these processes is essential to avoid catalyst deactivation. Abstract Structural dynamics of a Mn‐Na2WO4/SiO2 catalyst were detected...
Wed Jun 17, 2020 12:31
Creating synergies : The combination of more than one bioactive moiety resulted in an organometallic compound featuring a metal center, a 2‐pyridinecarbothioamide (PCA), and a hydroxamic acid, which is found in the anticancer drug vorinostat (SAHA). The compound displayed different modes of action than its components, supporting the development of non‐conventional anticancer drugs. Abstract The combination of more than one bioactive moiety in a multitargeted anticancer agent may result in synergistic...
Wed Jun 17, 2020 12:31
The big bucks : A wide range of fullerenes (buckyballs; C30–C114) and their building blocks (buckybowls with a stoichiometry of C10x H10) were detected in heavy crude oil by ultrahigh‐resolution mass spectrometry. Structural findings are supported by high‐level calculations at the DLPNO‐CCSD(T) level of theory, revealing for the first time the presence of fullerenes in low‐energy fossil materials on a molecular level. Abstract Buckyballs (fullerenes) were first reported over 30 years ago,...
Wed Jun 17, 2020 12:30
Radio‐photoluminescence in MOFs : The first metal–organic framework (MOF) to display radio‐photoluminescence (RPL) may lead to a new generation of RPL dosimeters showing advantages in terms of detection sensitivity, detection range, reusability, stability, and energy threshold over the existing commercial materials. Abstract Radio‐photoluminescence (RPL) materials display a distinct radiation‐induced permanent luminescence center, and therefore find application in the detection of ionizing...
Wed Jun 17, 2020 12:30
Crystal clear : Reported here is the synthesis of a centimeter‐sized AA′n −1Mn X3n +1 type perovskite, BDAPbI4 (BDA=NH3C4H8NH3), single crystal and its charge‐transport properties under X‐ray excitation. The crystal shows a staggered configuration of the [PbI6]4− layers, a band gap of 2.37 eV, and a low trap density of 3.1×109 cm−3. These crystals are promising candidates for the next generation of optoelectronic devices. Abstract Two‐dimensional (2D) AA′n −1Mn X3n +1 type halide perovskites...
Wed Jun 17, 2020 12:30
1,2‐Difluorobenzene serves as an electrolyte diluent to realize the high‐concentration effect in lithium metal batteries even at a bulk salt concentration near 2 m . The incorporation of this diluent also induces an anion‐associated lithium solvation structure to passivate lithium metal with a LiF‐rich solid‐electrolyte‐interphase (SEI) layer, thereby resulting in superior cyclability. Abstract In lithium metal batteries, electrolytes containing a high concentration of salts have demonstrated...
Wed Jun 17, 2020 12:28
Logic gates that read DNA molecules and return plasmonic chiroptical signals are presented. They are achieved on a DNA‐based platform that can direct the conformation of two gold nanorods. With delicate designs, the logic gates can operate in an adaptive manner, namely, they perform as AND gates at body temperature while as OR gates at cold storage temperature. Abstract Self‐assembled plasmonic logic gates that read DNA molecules as input and return plasmonic chiroptical signals as outputs...
Wed Jun 17, 2020 12:28
In control : Solute molecules are assembled in the microchannel between solvent crystal grains driven by solvent recrystallization. Benefitting from separate and adjustable assembly kinetics and thermodynamics of the solvent recrystallization, various molecules can be assembled into monodisperse amorphous and crystalline particles with precisely controlled sizes, down to that of single atoms. Abstract It has been long‐pursued but remains a challenge to precisely manipulate the molecular assembly...
Wed Jun 17, 2020 12:27
Multifaceted materials : Interface assembly enables the integration of magnetic particles and mesoporous materials to form advanced core–shell magnetic mesoporous materials for a variety of applications in catalysis, environmental remediation, and biomedicine. This Minireview summarizes progress made in the synthesis of core–shell magnetic mesoporous silica and the adjustment of key parameters, including pore size, morphology, and pore orientation. Abstract Interfacing magnetic particles with...
Wed Jun 17, 2020 12:27
More light in chemistry : This Minireview highlights the state‐of‐the‐art and emerging techniques in theoretical and computational photochemistry. This is a challenging and rapidly evolving field that relates time‐dependent spectroscopy with electronic structure theory and molecular dynamics for electronic excited states. Abstract Photochemistry is a fascinating branch of chemistry that is concerned with molecules and light. However, the importance of simulating light‐induced processes is reflected...
Wed Jun 17, 2020 12:27
Round round get around : A highly efficient metal‐catalyzed tandem cycloaddition reaction enables benzannulation to access cyclopolyarene nanorings of varied sizes from poly(arylene‐butadiynylene) macrocyclic precursors. Unique Möbius topology is manifested by the cyclopolyarene nanorings composed of an odd number of repeat units, whereas cylindrical tubular structures with radial conjugation are formed with an even number of repeat units. Abstract By harnessing a highly efficient metal‐catalyzed...
Wed Jun 17, 2020 12:27
Co‐localization of monomers, crosslinkers, and chain‐transfer agents (CTA) within self‐assembled bilayers in an aqueous suspension enabled the successful directed assembly of nanocapsules using a reversible addition‐fragmentation chain transfer (RAFT) process without compromising the polymerization kinetics. This study uncovered substantial influence of the organized medium on the course of the reaction, including differential reactivity based on placement and mobility of monomers, crosslinkers,...
Wed Jun 17, 2020 11:47
Hypoxia and acidic microenvironment play a vital role in tumor metastasis and angiogenesis, generally compromising the chemotherapeutic efficacy. This provides a tantalizing angle for the Pt(IV) prodrugs design to achieve effective and selective killing of solid tumors. Herein, two carbonic anhydrase IX (CAIX)‐targeted platinum(IV) prodrugs have been developed, named as CAIXplatins . Based on the strong affinity and inhibitory activity for CAIX, CAIXplatins can not only overcome hypoxia and acidic...
Wed Jun 17, 2020 11:44
A transition‐metal‐free C(sp 2 )‐C(sp 2 ) bond formation reaction via the cross‐coupling of diazo quinones with catechol boronic esters was developed. With this protocol, a variety of biaryls and alkenyl phenols were obtained in good to high yields under mild conditions. The reaction tolerates various functionalities and is applicable to the derivatization of pharmaceuticals and natural products. The synthetic utility of the method was demonstrated by the short synthesis of multi‐substituted...
Wed Jun 17, 2020 11:43
Aluminosilicate zeolites are synthesized under hydrothermal conditions in basic/alkaline medium in the pH range between 9 and 14. Here we report the synthesis of MFI‐type zeolite in acidic medium. The critical parameter determining the zeolite formation in acidic medium was found to be the isoelectric point (IEP) of gel particles. MFI‐type zeolite was synthesized above the isoelectric point of the employed silica source, where the silica species exhibit a negative charge and the paradigm of zeolite...
Wed Jun 17, 2020 11:42
The utilizations of omnipresent, thermodynamically stable amides and aliphatic C(sp3)–H bonds for various functionalizations are ongoing challenges in catalysis. In particular, the direct coupling between the two functional groups has not been realized. Here, we report the synergistic activation of the two challenging bonds, the amide C–N and unactivated aliphatic C(sp3)–H, via metallaphotoredox catalysis to directly acylate aliphatic C–H bond utilizing amides as stable and readily accessible acyl...
Wed Jun 17, 2020 11:42
Abstract As the heart matures during embryogenesis from its foetal stages, several structural and functional modifications take place to form the adult heart. This process of maturation is in large part due to an increased volume and work load of the heart to maintain proper circulation throughout the growing body. In recent years, it has been observed that these changes are reversed to some extent as a result of cardiac disease. The process by which this occurs has been characterized...
Wed Jun 17, 2020 15:58
Abstract Language‐related change‐detection processes are often investigated using syllables that are very simple in terms of phonological structure. However, phonological complexity is known to be challenging for young typically developing children and pathological populations. We investigated brain correlates of phonological processing and their age‐related changes with a passive change‐detection protocol including stimuli of varying phonological complexity, which allowed comparing responses to...
Wed Jun 17, 2020 13:41
Abstract Hypervigilance and attentional bias to threat faces with low‐spatial‐frequency (LSF) information have been found in individuals with social anxiety. The vigilance–avoidance hypothesis posits that socially anxious individuals exhibit initial vigilance and later avoidance to threatening cues. However, the temporal dynamics of these two processes in response to various LSF threats in social anxiety remain unclear. In the current study, we presented faces containing anger, disgust, and fear...
Wed Jun 17, 2020 13:34
We appreciate the interest in our study1 and wish to describe some aspects raised in the letter.
Wed Jun 17, 2020 03:00
Abstract Rationale The behavioral effects of the nicotine metabolites nornicotine and cotinine have not been investigated extensively. Objectives To evaluate the effects of nicotine, cotinine, and nornicotine, given alone or in combination, on locomotor activity and emission of ultrasonic vocalizations in male adult rats. ...
Thu Jun 18, 2020 03:00
Background/Aims: The number of different words (NDW), an essential measure of lexical diversity, is extremely valuable towards providing data regarding children’s language development. However, in Cyprus, practitioners are deprived of the opportunity to utilize NDW, as no normative data exist for toddlers who speak Cypriot Greek (CYG). Methods: The language samples of 36 monolingual CYG-speaking toddlers (aged 36, 40, 44, and 48 months) with a typical course of language development were collected...
Thu Jun 18, 2020 09:26
Abstract Purpose To evaluate changes in cerebral regional oxygen saturation (rSO2) after spinal anesthesia and compare the changes in rSO2 and systemic oxygenation between dexmedetomidine sedation and propofol sedation. Methods Thirty-six patients scheduled to undergo transurethral surgery under spinal anesthesia were randomly assigned to the dexmedetomidine...
Thu Jun 18, 2020 03:00
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