Prostate cancer (PCa) is the mostcommon non-cutaneous canceramong men in the United States [1]. For some men with non-aggressive PCa, active surveillance could be a viable option. Though survival rates are favorable for localized prostate cancer, treatment-related toxicity become important. The common treatment options for localized PCa include surgery, RT, androgen deprivation therapy (ADT), or a combination of the treatments, and all have associated treatment related toxicities [4–5]. Approximately...
Thu Jun 18, 2020 03:00
Thyroid, Ahead of Print.
Wed Jun 17, 2020 10:00
Nearly a year ago, the editors at the Annals of Allergy, Asthma & Immunology decided to put together an issue focused on vaccine technology and the importance of vaccination. At that time, we thought it was best to focus on respiratory virus vaccines (specifically for influenza and respiratory syncytial virus [RSV]), issues related to developing vaccines, and the distressing social movement against vaccination. Coronaviruses were not even considered. Now, we find ourselves in the middle of a...
06:41
We thank Chong-Neto and colleagues for their comments on our article “Risk factors for wheezing in primary health care settings in the tropics,”1 in which they recall the findings from the multicenter International Study of Wheezing in Infancy. Of interest in that study is the higher rate of recurrent wheeze (RW) reported by Latin American centers than that of European centers, with a high health care utilization by these infants. The risk factors related to RW are practically the same as those we...
06:41
Before the ravaging appearance of the severe acute respiratory syndrome coronavirus 2, influenza viruses have been among the major players in the history of health disasters over the past century.1,2 Because the 1918 Spanish flu pandemic claimed more than 50 million lives followed by annual resurgence of varying degrees of morbidity and mortality, the influenza vaccine program has driven platform development and global collaborative surveillance networks. These networks support the definition of...
06:41
We read with interest the article by Larenas-Linnemann et al1 about risk factors for wheezing in infancy in primary health care settings in the tropics. They concluded that infant wheezing is frequent in the tropics; most infants have their first episode between 2 and 4 months of age. More than 40% of them are brought to the emergency department, which indicates a considerable burden on health care costs. In addition, their study points out several possible risk and protective factors related to...
06:41
Atopic dermatitis (AD) is a chronic inflammatory skin disease that has been of great interest to the practicing allergists because, in childhood, it is recognized as the first step in the atopic march that leads to food allergy, allergic rhinitis, and asthma.1 Recent advances in our understanding of the complex pathobiology of AD reveal an important role for skin barrier dysfunction, genetic variation (particularly filaggrin mutations), environmental factors, and the microbiome and immune pathway...
06:41
Hereditary Angioedema (HAE) is a rare disease characterized by repeated episodes of bradykinergic driven angioedema that can involve the oral mucosa, pharynx, larynx, gastrointestinal system and extremities.1 The prevalence estimates for HAE ranges between 1 in 10,0002 to 1 in 150,000.3 HAE is categorized into 3 distinct subtypes: HAE Type I, the most common type, with a reduced quantity of C1 esterase inhibitor protein; HAE Type II, with decreased function of C1 esterase inhibitor protein, and lastly...
Thu Jun 18, 2020 03:00
Surgical Infections, Ahead of Print.
Wed Jun 17, 2020 10:00
Surgical Infections, Ahead of Print.
Wed Jun 17, 2020 10:00
Therapeutic Hypothermia and Temperature Management, Ahead of Print.
Wed Jun 17, 2020 10:00
The original version of this article unfortunately contained mistakes. The changes are shown below:
03:00
Extra flexibility. (Ashkan Forouzani via Unsplash/)Tablets can be perfect for long trips, waits in the doctor’s office, or a wind-down weeknight on the couch, but it doesn’t make a ton of sense to spring for one when your laptop does nearly the same thing. That’s why 2-in-1 laptops are becoming increasingly popular. You’ve got the stability of a keyboard for your work day and the portability of a tablet when it’s time to zone out. These 2-in-1s are becoming more refined by the day, so let’s take...
05:18
Deserts are some of the least touched biomes (Pixabay/)The idea of reserving half of the Earth for nature has been gaining traction among conservationists in recent years. Organizations like Nature Needs Half are pushing to protect 50 percent of the planet’s lands by 2030, saying it’s necessary to preserve biodiversity.That enormous area may seem impossible given all we’ve done to the planet, but a new analysis of global human impacts published in the journal Global Change Biology says there are...
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Research done over the past few months suggests that SARS-CoV-2, the virus that causes COVID-19, survives in the GI tract and can remain viable in your poop in a process charmingly known as “viral shedding.” (Unsplash/)When you live in the world, you are faced with two unavoidable truths: public bathrooms, generally speaking, are grotty, and yet, the time will come when you must visit one. Often poorly ventilated and haphazardly cleaned, these spaces (at even their most scrubbed) aren’t spots you’d...
Thu Jun 18, 2020 19:00
Control your outlets. ( Nathan Fertig via Unsplash/)We’ve firmly set foot in the automation age, and there’s no better place to start streamlining your life than in your own home. Smart plugs are a super quick and cost-effective solution for automating your lamps, fans, and other appliances to be voice-controlled, app-controlled, or powered on and off on a set schedule. Looking to turn on the lights in your yard at night? Grab a water-resistant smart plug. How about a whole set of office appliances...
Thu Jun 18, 2020 18:39
Keep your skills sharp at home. ( Ben Hershey via Unsplash/)Tennis is a lifestyle. Even when you’re home, consider checking out some tennis training gear to keep your forehand in tip-top shape. Whether you are already a pro or just starting lessons, there is no need to abandon practice if you can’t get to the club. Set some new goals for yourself and work at them in the privacy of your own home; soon you will be wow-ing your tennis partner, winning championships, and wishing you started training...
Thu Jun 18, 2020 18:13
Challenge yourself. (Amazon/)It’s hard to put a finger on what makes puzzles so satisfying. They’re simple enough for anyone to use but demand sustained focus and precision, and they offer a beautiful feeling upon completion. Whatever the reason, it’s undeniable that puzzles are a fun and pressure-free way to eat up hours of anyone’s day. For those of us looking to push our limits, there’s an entire category of 3D puzzles that take this concept to the next level, combining optical illusions with...
Thu Jun 18, 2020 17:59
A good place to dice. (Sébastien Marchand via Unsplash/)Cutting boards made from natural materials are a sustainable and stylish alternative to traditional plastic boards, and bamboo boards stand tall among them as some the best you can buy. Bamboo—which is technically a grass, and not a wood—grows extremely fast, making it an easily renewable resource and a safe and sanitary choice for kitchen use. With the right care and attention, a bamboo board can offer years of use as both a cutting board and...
Thu Jun 18, 2020 17:57
Bugs be gone. ( Chang Duong via Unsplash/)With warmer weather comes a million reasons to venture outdoors and enjoy the fresh air. Unfortunately, biting insects and mosquitoes usually follow suit, and these annoying critters can put a serious damper on your outdoor recreation, turning enjoyable activities into a miserable, itchy nightmare. Reclaim the great outdoors and keep your body bite-free no matter where you venture using these tried-and-true mosquito and bug repelling tools.Here are some of...
Thu Jun 18, 2020 17:51
With a simple design, this small organizational cabinet floats on a hidden French cleat and employs the same joinery used to build full sized cabinets. (David Kaleko/)Father’s Day is only a few days away, and if you’re still looking for a great gift for your dad, we’re not here to judge—we’re here to help. It’s hard to beat a handmade present, and the projects on this list are almost guaranteed to impress.And if Pops is particularly handy, you may want to suggest the two of you build one of these...
Thu Jun 18, 2020 16:32
We’ve been sending out radio signals for about into the galaxy for a century. Have other civilizations been doing the same? (Pixabay/)With astronomers constantly discovering new exoplanets orbiting distant stars and planetary scientists better understanding the warm, wet corners of our own solar system, the universe is looking more and more hospitable to life. Until someone spots far-off extraterrestrial technology or uncovers a more local microbe, the existence of extraterrestrial life will remain...
Thu Jun 18, 2020 12:00
SUMMARY:Coronavirus disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which spreads rapidly from person to person and manifests in most symptomatic patients as a respiratory illness, similar to prior SARS viruses. Neurologic manifestations of COVID-19 are uncommon; those so far reported include encephalopathy, stroke from large-vessel occlusion, and polyneuropathy. We report a unique neurologic complication of COVID-19 in a patient...
Thu Jun 18, 2020 17:06
SUMMARY:Despite the severity of coronavirus disease 2019 (COVID-19) being more frequently related to acute respiratory distress syndrome and acute cardiac and renal injuries, thromboembolic events have been increasingly reported. We report a unique series of young patients with COVID-19 presenting with cerebral venous system thrombosis. Three patients younger than 41 years of age with confirmed Severe Acute Respiratory Syndrome coronavirus 2 (SARS-Cov-2) infection had neurologic findings related...
Thu Jun 18, 2020 17:05
SUMMARY:There is growing evidence that Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has a neurotropic and neuroinvasive potential. In particular, neurologic complications associated with the infection by SARS-CoV-2 include strokes that may result from a dysregulated inflammatory response to the infection. We report an atypical deep cerebral vein thrombosis complicated with hemorrhagic venous infarction in a patient positive for SARS-CoV-2 with no risk factors for thrombosis.
Thu Jun 18, 2020 17:05
Thu Jun 18, 2020 17:04
BACKGROUND AND PURPOSE:For primary squamous cell carcinoma of the oral tongue, accurate assessment of tumor thickness and depth of invasion is critical for staging and operative management. Currently, typical imaging modalities used for preoperative staging are CT and MR imaging. Intraoperatively, CT or MR imaging cannot provide real-time guidance, and assessment by manual palpation is limited in precision. We investigated whether intraoperative sonography is a feasible technique for assessment of...
Thu Jun 18, 2020 16:58
BACKGROUND AND PURPOSE:Pathology and microbiology results for suspected spondylodiscitis on MR imaging are often negative in up to 70% of cases. We aimed to predict whether MR imaging features will add diagnostic value when combined with clinical biomarkers to predict positive findings of spondylodiscitis on pathology and/or microbiology from percutaneous biopsy.MATERIALS AND METHODS:In this retrospective single-center institutional review board–approved study, patients with radiologically suspected...
Thu Jun 18, 2020 16:58
SUMMARY:In the 2020 Final Rule, the Center for Medicare & Medicaid Services adopted a new coding structure and accepted the substantial increase in valuation for office/outpatient Evaluation and Management codes set to begin in 2021. Given budget neutrality requirements, the projected increase in reimbursement will require a reduction in the conversion factor to offset such increases. The aim is to inform neuroradiologists the impact of these proposed changes on reimbursement and the profession.
Thu Jun 18, 2020 16:55
BACKGROUND AND PURPOSE:Previous studies have reported that MCA bifurcation aneurysms usually emerge on inclined bifurcations; however, the reason is unclear. We designed this study to explore hemodynamic mechanisms that correlate with the initiation of MCA bifurcation aneurysms.MATERIALS AND METHODS:Fifty-four patients with unilateral MCA bifurcation aneurysms and 54 control patients were enrolled in this study after propensity score matching, and their clinical and CTA data were collected. We extracted...
Thu Jun 18, 2020 16:54
BACKGROUND AND PURPOSE:Early detection of residual or recurrent disease is important for effective salvage treatment in patients with head and neck cancer. Current National Comprehensive Cancer Network guidelines do not recommend standard surveillance imaging beyond 6 months unless there are worrisome signs or symptoms on clinical examination and offer vague guidelines for imaging of high-risk patients beyond that timeframe. Our goal was to evaluate the frequency of clinically occult recurrence in...
Thu Jun 18, 2020 16:53
BACKGROUND AND PURPOSE:Spine MR imaging plays a pivotal role in the diagnostic work-up of spontaneous intracranial hypotension. The aim of this study was to compare the diagnostic accuracy of unenhanced spine MR imaging and intrathecal gadolinium-enhanced spine MR imaging for identification and localization of CSF leaks in patients with spontaneous intracranial hypotension.MATERIALS AND METHODS:A retrospective study of patients with spontaneous intracranial hypotension examined from February 2013...
Thu Jun 18, 2020 16:51
IDH inhibitors have clinical activity in AML in part by differentiating blasts to mature myeloid cells. In the largest systematic analysis to date, differentiation syndrome was seen in 19% of patients treated with IDH inhibitors. Early recognition with uniform diagnostic criteria, as utilized in APL, may reduce subsequent complications.
Thu Jun 18, 2020 16:42
Purpose: Small cell lung cancer (SCLC) is the most lethal and aggressive subtype of lung carcinoma characterized by highly chemotherapy resistant recurrence in the majority of patients. To effectively treat SCLC we have developed a unique and novel IgG-like T-cell engaging bispecific antibody (ITE) that potently re-directs T-cells to specifically lyse SCLC cells expressing Delta-like ligand 3 (DLL3), an antigen that is frequently expressed on the cell surface of SCLC cells, with no to very little...
Thu Jun 18, 2020 16:42
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