Purpose: The incidence rates of colorectal cancers (CRC) are increasing in young adults. The objective of this study was to investigate genomic differences between tumor samples collected from younger and older patients with CRC. Experimental Design: DNA was extracted from 18,218 clinical specimens, followed by hybridization capture of 3,769 exons from 403 cancer-related genes and 47 introns of 19 genes commonly rearranged in cancer. Genomic alterations (GA) were determined, and association with...
Wed Jun 26, 2019 16:14
Purpose: Bendamustine and Rituximab (BR) has been established as a superior frontline therapy over R-CHOP in the treatment of follicular lymphoma (FL). 90Y-Ibritumomab tiuxetan (90YIT) is an effective consolidation strategy after chemotherapy induction. This prospective, single arm, multicenter, phase II trial evaluated the response rate, progression-free survival (PFS), and tolerability of BR followed by consolidation with 90YIT in patients with untreated FL. Experimental Design: The study included...
Wed Jun 26, 2019 16:14
Purpose: Cetuximab, which modulates immune responses, may affect the efficacy of subsequent immunotherapy. Here, we assessed outcomes with nivolumab, by prior cetuximab exposure, in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) who had experienced progression within 6 months of platinum-containing chemotherapy. Experimental Design: In the randomized, open-label, phase III CheckMate 141 trial, patients were randomized 2:1 to nivolumab 3 mg/kg every...
Tue Jun 25, 2019 16:22
Purpose: To investigate the clinical relevance of macrophages in liver metastasis of colorectal cancer and their influence on angiogenesis and patient survival. Moreover, to evaluate specific blood monocytes as markers of disease recurrence. Experimental Design: In a mouse model with spontaneous LM, the angiogenic characteristics of tumor- (TAMs) and metastasis- (MAMs) associated macrophages were evaluated. Macrophages and the vasculature from 130 primary tumor (pTU) and 123 liver metastasis (LM)...
Tue Jun 25, 2019 16:22
Purpose: The resistance to differentiation therapy and early death caused by fatal bleeding endangers the health of a significant proportion of APL patients. This study aims to investigate the molecular mechanisms of ATRA resistance and uncover new potential therapeutic strategies to block the rapid progression of early death. Experimental Design: The important role of TWIST1 in APL leukemogenesis was first determined by gain- and loss-of-function assays. We then performed in vivo and in vitro experiments...
Mon Jun 24, 2019 16:47
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