AbstractBackgroundEvidence linking breast size to breast cancer risk has been inconsistent, and its interpretation is often hampered by confounding factors such as body mass index (BMI). Here, we used linkage disequilibrium score regression and two-sample Mendelian randomization (MR) to examine the genetic associations between BMI, breast size and breast cancer risk.MethodsSummary-level genotype data from 23andMe, Inc (breast size, n = 33 790), the Breast Cancer Association Consortium (breast cancer...
Wed Jun 26, 2019 03:00
AbstractBackgroundIn many countries, an increased prevalence of obesity in pregnancy has coincided with a declining pubertal age. We aimed to explore the potential effect of maternal pre-pregnancy overweight and obesity on timing of puberty in sons and daughters.MethodsBetween 2012 and 2018, 15 819 of 22 439 invited children from the Danish National Birth Cohort, born 2000–03, provided half-yearly information from the age of 11 years on the pubertal milestones: Tanner stages, voice break, first ejaculation,...
Tue Jun 25, 2019 03:00
National Health and Aging Trends Study profile in a nutshellThe National Health and Aging Trends Study (NHATS) is designed to study population-level trends and individual-level dynamics in late-life functioning in the USA. NHATS also facilitates investigation of differences in disablement for various at-risk subgroups and of the economic and social consequences of disability from aged 65 through to the end of life.Adults ages 65 and older were sampled from the Medicare enrolment file and first interviewed...
Tue Jun 25, 2019 03:00
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