JI (AOP),

The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location [INFECTIOUS DISEASE AND HOST RESPONSE]

Key PointsCD69 is not required for the establishment of CD8+ TRM in every nonlymphoid tissue.In the kidney, CD69 is required for CD8+ TRM regardless of immunization approach.CD69 deficiency prevents generation of KLF2low TRM in the kidney.

JI (AOP)

Wed Jun 26, 2019 19:27

Thymus-Derived Regulatory T Cells Exhibit Foxp3 Epigenetic Modification and Phenotype Attenuation after Mating in Mice [CLINICAL AND HUMAN IMMUNOLOGY]

Key PointsSeminal fluid primes Treg cells to elicit tolerance of male alloantigens.Neuropilin-1+ Tregs of likely thymic origin are prevalent amongst responding T cells.Neuropilin-1+ Tregs exhibit Foxp3 TSDR demethylation after seminal fluid contact.

JI (AOP)

Wed Jun 26, 2019 19:27

Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2 [IMMUNE REGULATION]

Key PointsCOX-1 deficiency impaired TFH cell development during influenza infection and KLH immunization.COX-1–derived metabolite PGE2 and its receptors EP2/EP4 mediate the effect of COX-1 on TFH cells.

JI (AOP)

Wed Jun 26, 2019 19:27

Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells [IMMUNE SYSTEM DEVELOPMENT]

Key PointsREs critical for Foxn1 expression are in the first intron of Foxn1.These elements are necessary for Foxn1 expression in TECs.These elements are not required for Foxn1 expression in the skin.

JI (AOP)

Wed Jun 26, 2019 19:27

Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death [CUTTING EDGE]

Key PointsTAK1 protects macrophages from proinflammatory cell death in TLR and TNFRI signaling.The cell death machinery is dependent on active caspases and GSDMD processing.TAK1 in macrophages both positively and negatively controls host inflammatory responses.

JI (AOP)

Wed Jun 26, 2019 19:27

NK Cells Are Critical for Optimal Immunity to Experimental Trypanosoma congolense Infection [INFECTIOUS DISEASE AND HOST RESPONSE]

Key PointsDeficiency of NK cells leads to enhanced susceptibility to T. congolense infection.NK cells mediate protection during T. congolense infection via perforin.

JI (AOP)

Wed Jun 26, 2019 19:27