Cancers, Vol. 11, Pages 896: Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Naïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12Cancers doi: 10.3390/cancers11070896Authors: Autore Strati Innocenti Corrente Trentin Cortelezzi Visco Coscia Cuneo Gozzetti Mauro Frustaci Gentile Morabito Molica Falcucci D’Arena Murru Vincelli Efremov Ferretti Rigolin Vitale Tisi Reda Visentin Sica Foà Ferrajoli LaurentiChronic Lymphocytic Leukemia (CLL) patients with +12 have...
Wed Jun 26, 2019 03:00
Cancers, Vol. 11, Pages 893: Nerves and Pancreatic Cancer: New Insights into a Dangerous RelationshipCancers doi: 10.3390/cancers11070893Authors: Gasparini Pellegatta Crippa Lena Belfiori Doglioni Taveggia FalconiPerineural invasion (PNI) is defined as the presence of neoplastic cells along nerves and/or within the different layers of nervous fibers: epineural, perineural and endoneural spaces. In pancreatic cancer—particularly in pancreatic ductal adenocarcinoma (PDAC)—PNI has...
Wed Jun 26, 2019 03:00
Cancers, Vol. 11, Pages 894: B Cells as an Immune-Regulatory Signature in Ovarian CancerCancers doi: 10.3390/cancers11070894Authors: Gupta Chen Chaluvally-Raghavan PradeepIncreasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interactions among immune cells in the...
Wed Jun 26, 2019 03:00
Cancers, Vol. 11, Pages 895: Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer ModelsCancers doi: 10.3390/cancers11070895Authors: Mahalingam Carew Espitia Cool Giles de Jong NawrockiTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis that may be a promising agent in cancer therapy due to its selectivity toward tumor cells. However, many cancer cells are resistant to TRAIL due to defects in...
Wed Jun 26, 2019 03:00
Cancers, Vol. 11, Pages 892: Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer CellsCancers doi: 10.3390/cancers11070892Authors: Desir Wong Turbyville Chen Shetty Clark Zhai Romin Manova-Todorova Starr Nissley Steer Subramanian LouMutated forms of the RAS oncogene drive 30% of all cancers, but they cannot be targeted therapeutically using currently available drugs. The molecular and cellular mechanisms that create a...
Wed Jun 26, 2019 03:00
Cancers, Vol. 11, Pages 890: Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for CancerCancers doi: 10.3390/cancers11070890Authors: Alsereihi Schulten Bakhashab Saini Al-Hejin Hussein Effective diagnostic, prognostic and therapeutic biomarkers can help in tracking disease progress, predict patients’ survival, and considerably affect the drive for successful clinical management. The present...
Wed Jun 26, 2019 03:00
Cancers, Vol. 11, Pages 891: Salivary Extracellular Vesicle-Associated exRNA as Cancer BiomarkerCancers doi: 10.3390/cancers11070891Authors: Chiabotto Gai Deregibus CamussiExtracellular vesicles (EVs) secreted in biological fluids contain several transcripts of the cell of origin, which may modify the functions and phenotype of proximal and distant cells. Cancer-derived EVs may promote a favorable microenvironment for cancer growth and invasion by acting on stroma and endothelial cells and may favor...
Wed Jun 26, 2019 03:00
Cancers, Vol. 11, Pages 888: Exo-miRNAs as a New Tool for Liquid Biopsy in Lung CancerCancers doi: 10.3390/cancers11060888Authors:Orazio FortunatoPatrizia GaspariniMattia BoeriGabriella SozziLung cancer is the predominant cause of cancer-related deaths. The high mortality rates are mainly due to the lack of diagnosis before the cancer is at a late stage. Liquid biopsy is a promising technique that could allow early diagnosis of lung cancer and better treatment selection for patients. Cell-free microRNAs...
Tue Jun 25, 2019 03:00
Cancers, Vol. 11, Pages 889: Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the MechanismsCancers doi: 10.3390/cancers11060889Authors:Jacqueline KesslerTim HohmannAntje GüttlerMarina PetrenkoChristian OstheimerUrszula HohmannMatthias BacheFaramarz DehghaniDirk VordermarkThe presence of an isocitrate dehydrogenase 1 (IDH1) mutation is associated with a less aggressive phenotype, increased sensitivity...
Tue Jun 25, 2019 03:00
Cancers, Vol. 11, Pages 886: Systematic Analysis of Gene Expression in Lung Adenocarcinoma and Squamous Cell Carcinoma with a Case Study of FAM83A and FAM83BCancers doi: 10.3390/cancers11060886Authors:Ling CaiDanni LuoBo YaoDonghan M. YangShinYi LinLuc GirardRalph J. DeBerardinisJohn D. MinnaYang XieGuanghua XiaoIntroduction: In our previous study, we constructed a Lung Cancer Explorer (LCE) database housing lung cancer-specific expression data and clinical data from over 6700 patients in 56 studies....
Tue Jun 25, 2019 03:00
Cancers, Vol. 11, Pages 887: Utility of Circulating Cell-Free RNA Analysis for the Characterization of Global Transcriptome Profiles of Multiple Myeloma PatientsCancers doi: 10.3390/cancers11060887Authors:Maoshan ChenSridurga MithraprabhuMalarmathy RamachandranKawa ChoiTiffany KhongAndrew SpencerIn this study, we evaluated the utility of extracellular RNA (exRNA) derived from the plasma of multiple myeloma (MM) patients for whole transcriptome characterization. exRNA from 10 healthy controls (HC),...
Tue Jun 25, 2019 03:00
Cancers, Vol. 11, Pages 885: MiRNAs Are Involved in Tall Cell Morphology in Papillary Thyroid CarcinomaCancers doi: 10.3390/cancers11060885Authors:Laura A. BoosAnja SchmittHolger MochPaul KomminothCedric SimillionIlaria MarinoniYuri E. NikiforovMarina N. NikiforovaAurel PerrenMatthias S. DettmerFive percent of papillary thyroid carcinomas (PTC) show an adverse clinical outcome (ACO). The tall cell variant of papillary thyroid carcinomas (TCV) is a good predictor of an ACO, however, the identification...
Tue Jun 25, 2019 03:00
Cancers, Vol. 11, Pages 884: Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the OvaryCancers doi: 10.3390/cancers11060884Authors:Matthew DeanVivian JinTova M. BergstenJulia R. AustinDaniel D. LantvitAngela RussoJoanna E. BurdetteHigh-grade serous ovarian cancer (HGSOC) can originate in the fallopian tube and then spread to the ovary. Our objective was to evaluate the role of multicellular tumor spheroids (MTS) in ovarian metastasis. By...
Tue Jun 25, 2019 03:00
Cancers, Vol. 11, Pages 883: Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene ExpressionCancers doi: 10.3390/cancers11060883Authors:Tabea RiedlingerMarek BartkuhnTobias ZimmermannSandra B. HakeAndrea NistThorsten StieweMichael KrachtM. Lienhard SchmitzInhibitors of DNA topoisomerase I (TOP1), an enzyme relieving torsional stress of DNA by generating transient single-strand breaks, are clinically used to treat ovarian, small cell lung...
Tue Jun 25, 2019 03:00
Cancers, Vol. 11, Pages 882: Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAsCancers doi: 10.3390/cancers11060882Authors:Azadeh AmirnasrCaroline M.M. GitsPatricia F. van KuijkMarcel SmidAnne L.M. VriendsPiotr RutkowskiRaf SciotPatrick SchöffskiMaria Debiec-RychterStefan SleijferErik A. C. WiemerDespite the success of imatinib in advanced gastrointestinal stromal tumor (GIST) patients, 50% of the patients experience...
Mon Jun 24, 2019 03:00
Cancers, Vol. 11, Pages 881: (Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma—Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer PrognosisCancers doi: 10.3390/cancers11060881Authors:Maider BeitiaJon Danel Solano-IturriPeio ErrarteJulio Calvete-CandenasAlberto LoizateMari Carmen EtxezarragaBegoña SanzGorka Larrinaga(Pro)renin receptor (PRR) is a protein that takes part in several signaling pathways such as Renin Angiotensin System and Wnt signalling....
Mon Jun 24, 2019 03:00
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