Rearrangements in the anaplastic lymphoma kinase (ALK) gene are found in approximately 5% of non-small cell lung carcinoma (NSCLC). Here, we present a comprehensive genomic landscape of 11 ALK+ NSCLC patients and investigate its relationship with response to crizotinib. Using whole exome sequencing and RNAseq data, we identified 4 rare ALK fusion partners (HIP1, GCC2, ERC1 and SLC16A7), and 1 novel partner (CEP55). At the mutation level, TP53 was the most frequently mutated gene, and was only observed...
Wed Jun 26, 2019 17:36
Deregulation of the MYC transcription factor is a key driver in lymphomagenesis. MYC induces global changes in gene expression that contribute to cell growth, proliferation and oncogenesis by stimulating the activity of RNA polymerases. A key feature in its ability to stimulate RNA Pol II activity is recruitment of pTEFb, an elongation factor whose catalytic core comprises CDK9/cyclin T complexes. Hence, MYC expression and function may be susceptible to CDK9 inhibition. We conducted a pre-clinical...
Wed Jun 26, 2019 17:36
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