Publication date: 15 November 2019Source: Journal of Molecular Structure, Volume 1196Author(s): Tariq Munir, Arslan Mahmood, Muhammad Fakhar-e-Alam, Muhammad Imran, Amjad Sohail, Nasir Amin, Sadia Latif, Hafiz Ghullam Rasool, Fahad Shafiq, Haider Ali, Khalid MahmoodAbstractTreatment for different diseases has been revolutionized dramatically due to the advancements in the medical sciences, such as the practice of capped nanoparticles to treat carcinoma could be a promising strategy for future. For...
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Publication date: 15 November 2019Source: Journal of Molecular Structure, Volume 1196Author(s): Mukhlif Mohsin Slaihim, Fouad Saleih R. Al-Suede, Melati Khairuddean, Mohamed B. Khadeer Ahamed, Amin Malik Shah Abdul MajidAbstractIn the present study, two important starting materials and 18 new 1,2,4-triazole compounds with mono ring system have been synthesized and characterized. The mono system showed 16 compounds of a Schiff base moiety attached to the triazole ring which was prepared from the corresponding...
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Publication date: Available online 26 June 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Shi-Bo Cheng, Miao-Miao Chen, Yi-Ke Wang, Zi-Han Sun, Min Xie, Wei-Hua HuangAbstractCirculating tumor cells (CTCs), escaped from solid tumor to peripheral blood, are responsible for tumor metastasis and closely relevant to cancer progression. As one of the targets of “liquid biopsy”, CTCs play an important role in noninvasive tumor diagnosis. In the past decades, various microfluidic devices have...
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Analyst, 2019, Advance Article DOI: 10.1039/C9AN00725C, PaperHajime Shigeto, Takashi Ohtsuki, Akira Iizuka, Yasuto Akiyama, Shohei Yamamura PNA –DNA probes for detecting different types of EGFR mRNA harboring single nucleotide gene mutation were developed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
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Publication date: Available online 25 June 2019Source: Urology Case ReportsAuthor(s): Jerasit Surintrspanont, Anapat Sanpawat, Kewalee Sasiwimonphan, Piyada SitthideatphaiboonAbstractImmunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized systemic condition characterized by particular clinical, serologic, and pathologic features that are consistent across a wide range of organ systems. Herein, we present a rare case of IgG4-RD presenting as multiple inflammatory pseudotumors involving...
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Publication date: Available online 26 June 2019Source: Urology Case ReportsAuthor(s): Humam Hatem, Jörg LeifeldAbstractThe early intravesical Instillation of mitomycin C (MMC) is accepted as safe adjuvant therapy after TURBT by non- muscle- invasive bladder cancer if there is no perforation. In our case we report a female patient undergoing resection of papillary recurrent tumor on the anterior bladder wall. In the early postoperative period had the patient no complaints regarding to Instillation...
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We present a case of a 17-year-old boy who suffered a severe head trauma during a car accident. He had prolonged confinement in the supine position because of ongoing coma. The SMAS developed due to a progressive weight lost. Upper gastrointestinal Barium contrast study, fibroesophagogastroduodenoscopy (FEGDS), abdomen computed tomography scan (CT) were not specific and only, magnetic resonance imaging (MRI) findings suggested diagnosis of SMAS. As there was no response to the conservative treatment,...
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ConclusionsThe proposed nomogram demonstrated accurate prognostic prediction of DFS for CRLM patients with preoperative chemotherapy followed by hepatic resection. (Source: European Journal of Surgical Oncology (EJSO))
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ConclusionThere is overexpression of Her-2/neu in our local setting, and this observation is very relevant to any therapeutic decisions and management of these patients. (Source: European Journal of Surgical Oncology (EJSO))
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ConclusionProlonged survival can be achieved by exclusive and iterative local treatment combining surgery and RFA in a small proportion of patients with a first recurrence of isolated LMUM. (Source: European Journal of Surgical Oncology (EJSO))
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ConclusionsMRI-based radiomic signature is an independent prognostic factor for HNSCC patients. Nomogram based on radiomic signature and TNM stage shows promising in non-invasively and preoperatively predicting prognosis of HNSCC patient in clinical practice. (Source: European Journal of Radiology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 23:41
Central airway obstruction (CAO) is a dangerous and increasingly common problem. CAO refers to lesions causing narrowing of the trachea or mainstem bronchi and is generally divided into malignant and nonmalignant categories. These 2 entities may be caused by a variety of thoracic and extrathoracic diseases. Imaging is critical during the initial assessment of CAO and may help thoracic physicians focus the differential diagnosis and plan the safest and most appropriate diagnostic and therapeutic interventions....
Wed Jun 26, 2019 23:41
Interventional oncology and management of thoracic malignancies with ablative techniques are becoming ever more recognized therapeutic options. With increased understanding, development, and utility of the ablative techniques, the indications are expanding and efficacy improving. Lung cancer was among the first indications for lung ablation and remains most challenging with multiple therapeutic options. For inoperable patients, the current literature demonstrates equivalent survivals between ablation,...
Wed Jun 26, 2019 23:41
Esophageal surgery has become quite specialized, and both dedicated diagnostic and refined surgical techniques are required to deliver state-of-the-art care. The field has evolved to include endoscopic mucosal resection and radiofrequency ablation for early-stage esophageal cancer and minimally invasive esophagectomy with the reconstruction of a gastric conduit for carefully selected patients with esophageal cancer or those with “end-stage” esophagus from benign diseases. Reoperative esophageal surgery...
Wed Jun 26, 2019 23:41
Publication date: Available online 25 June 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Paolo A. Ascierto, Carlo Bifulco, Giuseppe Palmieri, Solange Peters, Nikoletta SidiropoulosAn enduring goal of personalized medicine in cancer is the ability to identify patients who are likely to respond to specific therapies. Our growing understanding of the biology and molecular signatures of individual tumor types has facilitated the identification of predictive biomarkers and has led to an increasing...
Wed Jun 26, 2019 23:05
In this study, five population databases plus the Catalog of Somatic Mutations in Cancer was employed to demonstrate the impact of changing the PF cut-off on assignment of variants as germline versus somatic. The 1% to 2% PF cut-offs widely used in bioinformatic pipelines result in high sensitivity for classification of somatic variants, but unnecessarily reduced sensitivity for germline variants. Using optimized PF cut-offs, the source of variants in TCGA data could be predicted with>95% accuracy....
Wed Jun 26, 2019 23:05
Conclusion: PTC is significantly associated with an impaired oncological outcome in patients undergoing RC for UC. PTC therefore represents an independent and easy to determine prognostic parameter for patients ’ oncological outcome. Intriguingly, PTC is significantly associated with an increased rate of PBT.Urol Int (Source: Urologia Internationalis)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in...
Wed Jun 26, 2019 13:29
Conclusion: The results suggested that FPB can provide more accurate results compared to SPB.Urol Int (Source: Urologia Internationalis)
Wed Jun 26, 2019 13:07
Publication date: Available online 25 June 2019Source: Gynecologic Oncology ReportsAuthor(s): Rodger Rothenberger, Amanda Jackson, Ady Kendler, Thomas Herzog, Caroline BillingsleyAbstractPerivascular epithelioid cell neoplasms (PEComas) are mesenchymal neoplasms originating from the perivascular epithelioid cell (PEC) line. The World Health Organization (WHO) further defines PEComa as “a mesenchymal tumor composed of histologically and immunohistochemically distinctive perivascular epithelioid cells”....
Wed Jun 26, 2019 22:39
Conclusions We reviewed and discussed unusual benign and malignant dermatopathology conditions that can affect the foreskin. (Source: Journal of Lower Genital Tract Disease)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 22:38
Conclusions Both methods of sampling were found to be acceptable to women. Self-sampling is cost-effective and could increase the screening coverage among underscreened populations. However, more information about the quality, reliability, and accuracy of self-sampling is needed to increase women's confidence about using to this method. (Source: Journal of Lower Genital Tract Disease)
Wed Jun 26, 2019 22:38
No abstract available (Source: Journal of Lower Genital Tract Disease)
Wed Jun 26, 2019 22:38
Objective The aim of this study was to use an electronic tablet–based education module to increase patient knowledge about human papillomavirus (HPV). Methods Patients presenting to an academic colposcopy clinic were first queried as to whether they had been infected with HPV. A quality improvement project was then conducted using a 4-question pretest assessing baseline knowledge about HPV and cancer, followed by a tablet-based education module and a 5-question posttest. Results Between June...
Wed Jun 26, 2019 22:38
ConclusionIt seems that human breast cancer and BLV infection in cattle could be associated using nested PCR technique. (Source: Microbial Pathogenesis)
Wed Jun 26, 2019 21:12
ConclusionsMore research is necessary to understand why cervical cancer screenings are not associated with receipt of an AFV. (Source: American Journal of Infection Control)
Wed Jun 26, 2019 21:11
Conclusions Group C, F, and G streptococci are common pathogens in patients with an underlying malignancy, particularly solid tumor malignancies. Their usual association with other pathogens furthers the need for combinatorial therapeutic strategies to combat polymicrobial infections. (Source: Infectious Diseases in Clinical Practice)
Wed Jun 26, 2019 21:11
Conclusions: Although KS incidence rates have decreased nationally, age, racial, and geographic disparities persist, including increasing risk among younger Black men and particularly elevated rates in some southern states and urban areas. Further research is needed to address racial and geographic AIDS-related KS disparities. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Wed Jun 26, 2019 21:11
Background: High-dose methotrexate (HD MTX) is usually administered as an inpatient to those with osteosarcoma. We prospectively tested the safety and feasibility of administering HD MTX in the ambulatory setting. Materials and Methods: In this single arm prospective observational study, eligible patients had previously completed 2 courses of HD MTX as an inpatient. On study, patients received MTX in hospital, discharged home and returned for daily assessment. Criteria to determine safety and...
Wed Jun 26, 2019 21:08
This study reconfirms that allogenic HCT is feasible in developing world with the overall survival and TFS comparable to that reported in Western literature and should be considered early in all TM patients with available matched sibling donors. (Source: Journal of Pediatric Hematology Oncology)
Wed Jun 26, 2019 21:08
A 17-year-old patient with Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis achieved first remission after immunochemotherapy (ICT). However, he had fever with an increase in soluble interleukin-2 receptor, but not in ferritin. Molecular analysis revealed augmented plasma and T-cell EBV loads and reappearance of clonal T cells. Despite achieving second remission, the T-cell EBV load at week 8 after second ICT was almost similar to that at week 8 after first ICT. Hence, cyclosporine...
Wed Jun 26, 2019 21:08
No abstract available (Source: Journal of Pediatric Hematology Oncology)
Wed Jun 26, 2019 21:08
The “Joint Outcomes Study” (JOS) demonstrated improved joint outcomes for patients receiving primary prophylaxis versus on-demand therapy. The impact of primary prophylaxis on inpatient health care utilization is not well-defined. To evaluate changes in hospitalization care of children with hemophilia before and after the 2007 JOS publication, this study utilized the Pediatric Health Information System (PHIS) to evaluate admissions for patients with hemophilia A or B (age, 2 to 7) admitted between...
Wed Jun 26, 2019 21:08
No abstract available (Source: Journal of Pediatric Hematology Oncology)
Wed Jun 26, 2019 21:08
Literature on high-dose chemotherapy followed by autologous stem cell rescue in relapsed retinoblastoma is limited to (Source: Journal of Pediatric Hematology Oncology)
Wed Jun 26, 2019 21:08
This report describes 2 cases of MALT lymphoma in children with Sjogren syndrome. A 15-year-old girl developed MALT lymphoma of the parotid gland as the presenting symptom of Sjogren syndrome. In the second case, a 15-year-old boy with known Sjogren syndrome presenting mainly with arthritis was diagnosed with MALT lymphoma, also of the parotid gland. With early diagnosis and treatment, outcomes in pediatric MALT lymphoma are generally encouraging. Pediatric oncology specialists should be aware of...
Wed Jun 26, 2019 21:08
Congenital neuroblastoma with placental involvement is exceptionally rare, but mortality is high. Detailed examination of placenta including MYCN amplification and segmental chromosomal aberrations should be performed in all suspected cases, as it is noninvasive and readily available. Maternal dissemination has not been reported. In this manuscript, we describe an infant with placental diagnosis of MYCN nonamplified congenital neuroblastoma. This is the first report of a recurrence of congenital...
Wed Jun 26, 2019 21:08
Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal syndrome of abnormal T-cell activation and cytokine production, which can be familial or secondary in nature. Although HLH can occur concomitantly with lymphomas, the development of HLH alongside Hodgkin lymphoma in children is unusual. Here we report the diagnostic evaluation and clinical course of 2 pediatric cases of HLH secondary to lymphocyte-depleted classic Hodgkin lymphoma. These cases highlight the need to be vigilant for...
Wed Jun 26, 2019 21:08
Independence from regular transfusions is the hallmark of nontransfusion-dependent thalassemia (NTDT). However, the associated complications need anticipation and screening. One such complication is a hypercoagulable state predisposing to development of thrombosis. We evaluated children with NTDT>10 years of age for prevalence of neuroimaging abnormalities (NIA) and identified associated risk factors. In total, 29 patients were evaluated. Blood counts, serum ferritin, protein C, protein S, antithrombin...
Wed Jun 26, 2019 21:08
We describe a case of c-KIT (D816V) mutation-positive fatal diffuse cutaneous mastocytosis with systemic involvement of the gastrointestinal tract and associated malabsorption and hepatosplenomegaly associated with mast cell mediator release symptoms. (Source: Journal of Pediatric Hematology Oncology)
Wed Jun 26, 2019 21:08
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease associated with immune system hyperactivation and the appearance of serious systemic disturbances. The purpose of this study was an assessment of natural killer (NK) cell disturbances in a group of children with clinical signs of HLH. A total of 43 children with HLH and 17 healthy children were enrolled in the study. NK phenotyping, intracellular perforin staining, and cytotoxicity tests were performed by using the flow cytometry...
Wed Jun 26, 2019 21:08
Epstein-Barr virus (EBV)–positive aggressive natural killer-cell leukemia (ANKL) is a rare malignancy of mature natural killer cells, with a very poor survival rate. Patients have a rapidly declining clinical course and a poor prognosis, with a median survival of only a few months. Herein, we describe a 16-year-old boy who was diagnosed with EBV-positive ANKL and successfully treated using combination chemotherapy and a subsequent allogeneic hematopoietic stem cell transplantation (alloHSCT). The...
Wed Jun 26, 2019 21:08
Iron refractory iron deficiency anemia is an autosomal recessive disorder arising from defects in iron metabolism that cause microcytic anemia to grow resistant to treatment. The patients usually do not respond to orally administered iron treatment and partially respond to intravenous iron administration. Mutations of TMPRSS6 gene which encodes matriptase-2 are the main cause of the disorder. Here, we describe the case of a 6-month-old Syrian boy who had hypochromic-microcytic anemia and normal ferritin...
Wed Jun 26, 2019 21:08
No abstract available (Source: Journal of Pediatric Hematology Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 21:08
This article describes a pediatric patient with metastatic medullary thyroid cancer secondary to sporadic multiple endocrine neoplasia 2B, treated with vandetanib. At presentation, he had an inoperable primary tumor, with carotid encasement, and pulmonary metastases. Vandetanib induced a significant response: calcitonin and carcinoembryonic antigen levels both fell considerably, primary tumor maximal diameter decreased by 68%, and pulmonary metastases became no longer detectable. This allowed surgical...
Wed Jun 26, 2019 21:08
We report the measurable residual disease kinetics from a child with FLT3-internal tandem duplication acute myeloid leukemia where sequential WT1 monitoring in peripheral blood-guided withdrawal of immunosuppression. (Source: Journal of Pediatric Hematology Oncology)
Wed Jun 26, 2019 21:08
We describe a young female patient with ferroportin disease, which was confirmed from excess iron deposition within hepatocytes and by identifying a heterozygous variant p.Cys326Phe in SLC40A1. She had been followed without phlebotomy. Liver histology at age 13 years revealed iron deposition progression. Phlebotomy was initiated and her iron markers and imaging findings improved without severe adverse effects. Therapeutic phlebotomy for children is effective and well-tolerated and should be considered...
Wed Jun 26, 2019 21:08
Conclusions: This case highlights the importance of timely consideration of osteosarcoma in an infant, when the clinical presentation and medical imaging are consistent with that diagnosis. (Source: Journal of Pediatric Hematology Oncology)
Wed Jun 26, 2019 21:08
We report a 5-month old exclusively breastfed full-term infant with emesis, lethargy, progressive pancytopenia, hemolysis, hypofibrinogenemia, elevated lactate dehydrogenase and a hypercellular bone marrow with dyserythropoiesis. The B12 level in the serum was undetectable. The infant’s lethargy resolved within 48 hours of intramuscular B12 injection, followed by rapid improvement of pancytopenia. The asymptomatic mother had a normal hemoglobin and mean corpuscular volume, but undetectable B12 level...
Wed Jun 26, 2019 21:08
Conclusions: PFP is mostly asymptomatic, and its diagnosis is incidental. Only further 4 pediatric cases were reported in the literature. Our case confirms that gonadal-sparing surgery is an optimal treatment. (Source: Journal of Pediatric Hematology Oncology)
Wed Jun 26, 2019 21:08
In total, 74 pediatric oncology patients with hematologic malignancies (n=56) or solid tumors (n=18) and a median age of 78.5 months were included in this prospective study. The aims were to assess malnutrition risks and nutritional status over a 6-month treatment period measured at regular intervals. The rate of patients with high risk for malnutrition at diagnosis was 28.4% by Screening Tool for Risk of Impaired Nutritional Status and Growth tool and 36.5% by Pediatric Yorkhill Malnutrition Score....
Wed Jun 26, 2019 21:08
Li-Fraumeni syndrome is a kind of hereditary cancer predisposition syndromes, and is caused by TP53 gene mutation. Adrenocortical carcinoma (ACC) is commonly described as the most closely related tumor with this disease. Here, we present a case of a male infant with composite ACC and neuroblastoma who inherited a TP53 gene mutation from his mother, a 20-year-old carrier without any tumor to date. This TP53 gene mutation may be pathogenic and lead to composite malignancies of ACC and neuroblastoma....
Wed Jun 26, 2019 21:08
We examined immune reconstitution (T cells, B cells, and NK cells) at defined timepoints in 147 children who received 182 HSCTs. Differences in the time course of immune reconstitution were analyzed in autologous versus allogeneic HSCT. We identified a quicker immune reconstitution in the T-cell compartment, especially in the CD4 and naive subset after autologous HSCT, whereas recipients of allogeneic transplants showed a higher TCRgd proportion. B-cell reconstitution showed a delayed immune reconstitution...
Wed Jun 26, 2019 21:08
The GATA family of DNA binding proteins consists of six different transcription factors (GATA1-6), each with diverse biologic function. The GATA2 protein has been shown to be vital for proliferation and maintenance of hematopoietic stem cells; mutations result in variable phenotypes including myelodysplastic syndrome. (Source: Journal of Pediatric Hematology Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100%...
Wed Jun 26, 2019 21:08
Fever in a neutropenic oncology patient requires rapid initiation of effective empiric antibiotics to prevent mortality. We evaluated the appropriateness of our current empiric antibiotic regimen by assessing local antibiotic-susceptibility patterns in our pediatric oncology patients, and comparing them to the general pediatric patterns in our hospital. All blood culture isolates from pediatric oncology patients were reviewed over a 3-year period. Gram-negative and Gram-positive organisms were reviewed...
Wed Jun 26, 2019 21:08
CD19 chimeric antigen receptor T-cell (CART) therapy has revolutionized the treatment of patients with relapsed/refractory hematologic malignancies, especially B-cell acute lymphoblastic leukemia. As CART immunotherapy expands from clinical trials to FDA-approved treatments, a consensus among oncologists and hematopoietic cell transplant (HCT) physicians is needed to identify which patients may benefit from consolidative HCT post-CART therapy. Here, we review CD19 CART therapy and the outcomes of...
Wed Jun 26, 2019 21:08
We report the use of initial systemic therapy with oral sirolimus (SIR) and IV zoledronic acid (ZA) to induce a sustained clinical response and avoidance of amputation in a 6-year-old boy. At 37 months after diagnosis, our patient remains in sustained clinical remission as documented by x-ray, MRI, and PET-CT with return of normal mobility/activity and resolution of swelling and pain. Literature review identified 20 cases of pediatric and young adult patients with PMH, of which 7 received some form...
Wed Jun 26, 2019 21:08
Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) in children had a worse outcome before the use of tyrosine kinase inhibitors. We have evaluated the demographics and outcome of Ph+ ALL patients treated with imatinib without blood marrow transplantation. Of the 206 children with ALL registered for treatment, the demographic data of 15 Ph+ ALL patients were compared with the remaining Ph− patients. Imatinib (340 mg/m2) was started on day 5 (D5) of induction in Ph+ patients, and their...
Wed Jun 26, 2019 21:08
Conclusions: Elevated Ang-2 highlights the role of angiogenesis in the pathophysiology of SCD and may be considered a promising marker for screening of patients at risk of sickle retinopathy and vascular dysfunction. (Source: Journal of Pediatric Hematology Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Wed Jun 26, 2019 21:08
A nationwide shortage of intravenous (IV) sodium bicarbonate required institutions to explore alternative options for urinary alkalinization for high-dose methotrexate (HDMTX). Children’s Hospital Colorado implemented a protocol utilizing oral alkalinizing agents as alternatives to intravenous sodium bicarbonate during the shortage. The purpose of this study was to determine the safety and efficacy of oral alkalinization strategies for HDMTX administration. This retrospective study was conducted...
Wed Jun 26, 2019 21:08
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. An overview of studies on the frequency and determinants of IFI in pediatric oncology patients in nonallogeneic stem cell transplantation settings is lacking. We performed a literature review in Pubmed and Embase, and included 13 prospective and 23 retrospective studies. The IFI frequency (proven/probable based on EORTC criteria) in nonallogeneic stem cell transplantation pediatric cancer...
Wed Jun 26, 2019 21:08
Introduction: The international normalized ratio (INR), a standardized method of reporting the prothrombin time, can be a surrogate marker of the vitamin K-dependent coagulation pathways. Objective: To evaluate the relationship between INR measurements in the first 48 hours of life and subsequent development of intraventricular hemorrhage (IVH) in extremely preterm infants. Materials and Methods: A single-center retrospective, observational cohort study of infants born at (Source: Journal...
Wed Jun 26, 2019 21:08
Publication date: Available online 26 June 2019Source: Hepatobiliary & Pancreatic Diseases InternationalAuthor(s): Feng Li, Quan-Wa Bao, Liu-Yi-Qi Jiang, Qi-Lin Huang, Xu Zhang, Ju-Xiang Chen (Source: Hepatobiliary and Pancreatic Diseases International)
Wed Jun 26, 2019 21:03
Publication date: Available online 26 June 2019Source: Hepatobiliary & Pancreatic Diseases InternationalAuthor(s): Xiao Xu, Jun Chen, Qiang Wei, Zhi-Kun Liu, Zhe Yang, Ming Zhang, Guo-Ying Wang, Jie Gao, Zhao-Xu Yang, Wen-Yuan Guo, Tong-Hai Xing, Zhou Shao, Qin-Fen Xie, Shu-Sen Zheng (Source: Hepatobiliary and Pancreatic Diseases International)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 21:03
Publication date: Available online 11 June 2019Source: Hepatobiliary & Pancreatic Diseases InternationalAuthor(s): Zhao Li, Ji-Ye Zhu (Source: Hepatobiliary and Pancreatic Diseases International)
Wed Jun 26, 2019 21:03
We describe the management of chronic hypomagnesemia and dehydration secondary to a high-output ileostomy following radiation and chemotherapy for anal squamous cell carcinoma with intermittent home-based subcutaneous magnesium infusions in a 61-year-old female with a history of Crohn ’s disease and multiple bowel resections. Despite aggressive management with intravenous magnesium sulfate and oral magnesium glucoheptonate over 8 months, 49% of her magnesium concentrations were #x3c;0.60 mmol/L (mean...
Wed Jun 26, 2019 13:52
The Fontan circulation alters a patient ’s physiology and imparts long-term risks related to chronically elevated systemic venous pressure. An increasing number of patients with Fontan physiology are surviving into adulthood and are at risk of hepatic sequalae. The ideal timeline and method of hepatic surveillance in the Fontan populati on remains to be defined. In this case, the patient was diagnosed with hepatocellular carcinoma more than 20 years after undergoing the Fontan procedure and was a...
Wed Jun 26, 2019 13:52
The DNA repair system is essential for the maintenance of genome integrity and is mainly investigated in the areas of aging and cancer. The DNA repair system is strikingly cell-type specific, depending on the expression of DNA repair factors; therefore, different DNA repair systems may exist in each type of kidney cell. Importance of DNA repair in the kidney is suggested by renal phenotypes caused by both genetic mutations in the DNA repair pathway and increased stimuli of DNA damage. Recently, we...
Wed Jun 26, 2019 13:27
In conclusion, this study provides the novel insight into the mechanism of MH mediated growth arrest in subtype irrespective breast cancer progression.Graphical abstract (Source: Pharmacological Research)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 20:16
In conclusion, our data verifies that lncRNA POU3 F3, induced by transcription factor SP1, acts as an oncogene in the cervical cancer tumorigenesis via regulating miR-127-5p/FOXD1 axis, providing a possible therapeutic target for cervical cancer.Graphical Abstract (Source: Biomedicine and Pharmacotherapy)
Wed Jun 26, 2019 20:16
In conclusion, SNHG14 silencing suppressed NSCLC progression at least partly by miR-34a/HMGB1 axis in vitroand promoted NSCLC cell sensitivity to CDDP, highlighting that SNHG14 might be a potential target for NSCLC therapy.Graphical abstractThe mechanism schematic model by SNHG14/miR-34a/HMGB1 axis. SNHG14 expression was decreased in NSCLC cells by transfection of si-SNHG14. Then, miR-34a expression was upregulated. Next, upregulated miR-34a inhibited HMGB1 expression. Finally, low HMGB1 level repressed...
Wed Jun 26, 2019 20:16
Publication date: September 2019Source: Biomedicine & Pharmacotherapy, Volume 117Author(s): Tao Duan, Zhuobin Xu, Fumou Sun, Yang Wang, Juan Zhang, Chen Luo, Min WangAbstractBreast cancer is a fairly common cancer with high mortality in women worldwide. Targeted nano-drug delivery system for breast cancer treatment has achieved encouraging results, because of increased drug concentration at the tumor site, thereby improving biocompatibility and blood half-life while reducing chemoresistance....
Wed Jun 26, 2019 20:16
Conclusions: The risk of malignancy of 7.6% and 6.8% was high, considering that patients with malignant FNA, suspicious FNA, or clinical findings indicating malignancy were excluded, and 2.2% of these malignancies were stages T2 –4. In cases with solitary solid tumour on ultrasound, the risk of malignancy should not be ignored, even with benign FNA.Eur Thyroid J (Source: European Thyroid Journal)
Wed Jun 26, 2019 11:58
Conclusion: This study found that both ATA RSS-2009 and ATA RTR-2015 are reliable in predicting outcome in DTC patients after initial treatment. However, the response to initial therapy at 1 year predicted outcome more accurately than the initial risk status.Eur Thyroid J (Source: European Thyroid Journal)
Wed Jun 26, 2019 11:15
Contributors : Ming Xu ; Jiangmin Zhao ; Bin Jiang ; Le Li ; Haihua Yuan ; Hongxiu HanSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo determine the circRNA expression profile in early stage lung adenocarcinoma and matched non-tumor tissues, we used circRNA microArray analysis form Arraystar to examine the expression of circRNAsLung adenocarcinoma, a form of NSCLC with high lethality at advanced stage, is becoming more popular in women, non- or never-smokers, and even young...
Wed Jun 26, 2019 06:00
Contributors : Roland Sch üle ; Dominica Willmann ; Eric MetzgerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe aim of the RNA-seq was to identify the KMT9 transcriptome in PC-3M cells. The MCF10A breast epithelial cells that do not express KMT9a were used to show that the siRNA against KMT9 show no off-target effects. (Source: GEO: Gene Expression Omnibus)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
Wed Jun 26, 2019 06:00
Contributors : Yasumasa Kanai ; Akiko Katsumata ; Yoko Ono ; Toshio OtaSeries Type : Expression profiling by arrayOrganism : Mus musculusObjective The risk of ulcerative colitis (UC)-associated colorectal cancer (CRC) increases with the duration of UC. Oral 5-aminosalicylic acid (5-ASA) formulations are the first-line treatment for mild-to-moderate UC; nevertheless, preventive effect of oral 5-aminosalicylic acid (5-ASA) formulations on UC-associated CRC remains unsolved. We investigated the impact...
Wed Jun 26, 2019 06:00
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00136 (Source: Molecular Pharmaceutics)
Wed Jun 26, 2019 06:00
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.Posttranslational modifications of histones such as methylation regulate chromatin structure and gene expression. Methylation of histone lysine residues is generally performed by SET domain methyltransferases. Here, we identify the heterodimeric C21orf127/TRMT112 complex as a histone methyltransferase....
Wed Jun 26, 2019 06:00
The objectives of this study is to identify KMT9a, KMT9b, and H4K12me1 locations by ChIP-seq in the androgen-independent PC-3M prostate cancer cells and to show that upon KMT9a knockdown the levels of H4K12me1 mark decrease. (Source: GEO: Gene Expression Omnibus)
Wed Jun 26, 2019 06:00
Contributors : Roland Sch üle ; Dominica Willmann ; Eric MetzgerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe aim of the study is to identify KMT9a target genes in PC-3M cells (Source: GEO: Gene Expression Omnibus)
Wed Jun 26, 2019 06:00
Contributors : Jianfeng Huang ; Angeles Duran ; Miguel Reina-Campos ; Maria T Diaz-Meco ; Jorge MoscatSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is a leading risk factor for tumorigenesis and there is emerging support for a positive association between obesity and a more aggressive fatal prostate cancer. However, a complete understanding of the specific cross-talk between adipocytes and tumor cells in vivo and independently of dietary contributions...
Wed Jun 26, 2019 06:00
Contributors : Heng Xu ; Hao Zhang ; Cheng Luo ; Xu-Wen LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTwo novel polyketides, ocellatusones A and B (1 and 2), characterized by either an uncommon oxatricyclo[4.2.1.02,4]nonane skeleton (1) or a mesitylene connected dimethylfuran-3(2H)-one nucleus (2), were isolated in racemic forms from the South China Sea sacoglossan Placobranchus ocellatus, together with seven uncommon polypropionates (3, 4a,4d, 5, and 6)....
Wed Jun 26, 2019 06:00
Contributors : Pedro P Nicolau-Neto ; Paulo P SantosSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe goal was to identify the differently expressed genes between esophageal tumor and nonmalignant surrounding mucosa (Source: GEO: Gene Expression Omnibus)
Wed Jun 26, 2019 06:00
Contributors : Xiuxing Wang ; Stephen C Mack ; Tyler E Miller ; Leo J Kim ; Jeremy N RichSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGlioblastomas are lethal cancers defined by inevitable disease recurrence after maximal surgical and chemoradiological interventions. To identify possible dependencies in glioblastomas undetected by whole transcriptome sequencing, we examined the enhancer landscape marked by histone 3 lysine 27 acetylation (H3K27ac)...
Wed Jun 26, 2019 06:00
As a general principle, a key indicator of the prognosis of a given primary malignant tumor is its size. Simply put, at the time of cancer diagnosis, it is better to have a small tumor than a large one. The tenet that size matters applies not only to malignant tumors developing in parenchymal organs but also cutaneous cancers. The metastatic potential of squamous cell carcinoma, the second most common cutaneous malignant condition, is highly or directly correlated with tumor size. At sizes smaller...
Wed Jun 26, 2019 02:00
This cohort study investigates the precision and prognostic value of calculated tumor area among patients with cutaneous malignant melanoma. (Source: JAMA Dermatology)
Wed Jun 26, 2019 02:00
The purpose of a pharmacogenomic approach is to tailor treatment on the basis of individual human genotype. This strategy is becoming increasingly common in medicine, and important results have been obtained in oncologic and antimicrobial therapies. The rapid technological developments and availability of innovative methodologies have revealed the existence of numerous genotypes that can influence the action of medications, and that a true “individualized” approach could become in the future a reality...
Wed Jun 26, 2019 00:00
AbstractBasaloid squamous cell carcinoma (BSCC) is a variant of oral squamous cell carcinoma, is an aggressive, high grade variant and rare subtype of the head and neck SCC that less common in tonsils. Here, we are reporting a case of BSCC involving the tonsil with an extension on the cervical lymph node region. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Wed Jun 26, 2019 00:00
The objective of this review is to provide comprehensive insight on the effects of Chinese herbal medicines on angiogenesis by regulating HIF-1 pathways in both cancer and ischemic stroke. (Source: Frontiers in Pharmacology)
Wed Jun 26, 2019 00:00
Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated in the progression of several types of cancer. However, its role in medulloblastoma (MB), the most common type of malignant brain tumor afflicting children, remains unclear. Here we show that selective TrkB inhibition with the small molecule compound...
Wed Jun 26, 2019 00:00
Interstitial fluid pressure (IFP) in tumor tissue was significantly higher than normal tissue, which reduced the effective of therapeutic drugs. There are many methods to decrease the IFP level, such as normalizing blood vessel, decreasing the content of hyaluronic acid and collagen fibers in extracellular matrix (ECM), and recovering lymphatic function. Reducing tumor IFP may become a new way in cancer therapy. Our research aimed to focus on the relationship and mechanism between ultrasound combined...
Wed Jun 26, 2019 00:00
Conclusions: The results indicate that DT-010 overcomes Dox resistance in human breast cancer cells through a dual action via simultaneously inhibiting P-gp-mediated drug efflux and influencing metabolic process. (Source: Frontiers in Pharmacology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Wed Jun 26, 2019 00:00
In this study, the in vitro proliferation inhibition effect of SAN in GC cells was determined using CCK-8 assay, the in vivo antitumor effect of SAN was evaluated in mice with xenotransplanted tumor. The mechanism underlying the antitumor activity of SAN was explored by gene microarray assay and bioinformatics analysis. The levels of differentially expressed miRNAs and target genes were verified by real-time RT-PCR and immunohistochemistry. SAN inhibited the proliferation of BGC-823 cells in a concentration-dependent...
Wed Jun 26, 2019 00:00
. (Source: OncoImmunology)
Wed Jun 26, 2019 00:00
Cancers, Vol. 11, Pages 896: Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Naïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12 Cancers doi: 10.3390/cancers11070896 Authors: Autore Strati Innocenti Corrente Trentin Cortelezzi Visco Coscia Cuneo Gozzetti Mauro Frustaci Gentile Morabito Molica Falcucci D’Arena Murru Vincelli Efremov Ferretti Rigolin Vitale Tisi...
Wed Jun 26, 2019 00:00
ConclusionsIn the absence of barriers such as cost and accessibility, this Canadian sample still reported several challenges to disclosure and colonoscopy adherence. Future research should explore interventions such as motivational interviewing to improve proband disclosure and to increase FDR adherence to colonoscopy. (Source: Hereditary Cancer in Clinical Practice)
Wed Jun 26, 2019 00:00
ConclusionA radial T2 weighted multislice pulse sequence was superior to a single-shot fast-spin echo sequence for visualization of the urethra in the setting of MR Simulation for prostate cancer. (Source: Practical Radiation Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 19:14
Publication date: Available online 26 June 2019Source: Practical Radiation OncologyAuthor(s): Trevor J. Royce (Source: Practical Radiation Oncology)
Wed Jun 26, 2019 19:14
ConclusionIn select patients, NHDO principles used in SBRT optimization can be applied to CF-RT. NHDO results in increased tumor dose, reduction in select OAR dose objectives, and maintenance of target coverage and normal tissue constraints when compared to HDO. Our data demonstrate that principles of NHDO used in SBRT can also improve plan quality in CF-RT. (Source: Practical Radiation Oncology)
Wed Jun 26, 2019 19:14
In conclusion, given the poor outcome and the newly reported evidence of PD-L1 expression in patients with PBL, further exploration of check point inhibitor therapy is warranted. (Source: Clinical Lymphoma Myeloma and Leukemia)
Wed Jun 26, 2019 19:13
ConclusionsRegional cancer registry data can be used to define incidence patterns and disparities in outcomes across NHL subtypes to help define key targets for interventions in a catchment area. (Source: Clinical Lymphoma Myeloma and Leukemia)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 19:13
Pain after surgery remains a major health problem, calling for optimized treatment regimens to maximize the efficacy of pharmacological interventions. In this randomized controlled trial, we tested in a routine surgical treatment setting whether postoperative pain can be reduced by a brief preoperative intervention, ie, positive verbal suggestions in combination with sham acupuncture, designed to optimize treatment expectations. We hypothesized that the expectancy intervention as add-on to patient-controlled...
Wed Jun 26, 2019 19:08
In conclusion, our findings indicate that early exposure to regional hypothermia alleviates paclitaxel-induced peripheral neuropathy. Therapeutic hypothermia may therefore represent an economical and nonpharmaceutical preventive strategy for CIPN in patients with localized solid tumors. (Source: Pain)
Wed Jun 26, 2019 19:08
Patients with stage I testicular germ cell tumors have a long life expectancy, but the tumors have a potential to relapse after treatment. Although relapse is observed within a few years in most cases, late relapse over 10 years after initial treatment has also been reported in patients with stage I testicular germ cell tumors. We encountered a case of testicular seminoma that developed mediastinal lymph node metastasis 13 years after radical surgery for the primary tumor. The relapsed disease progressed...
Wed Jun 26, 2019 14:41
We report a 76-year-old patient who was diagnosed with concurrent accessory breast and primary lung cancer, both were positive for somatic BRCA-2 (E1593D) mutation. He received concurrent radiation and platinum-based chemotherapy for lung cancer with good response, but breast cancer progressed in about 8 months, and further progressed after single agent anastrozole in 10 months. Next Generation Sequencing (NGS) of breast cancer was also positive forCCND1 (Cyclin D1) and FGFR1 amplifications. Despite...
Wed Jun 26, 2019 14:41
We present two cases suspected of being AM prior to surgery that were pathologically diagnosed as low-grade appendiceal mucinous neoplasms. Each case progressed without developing PP. The surgical procedures we chose are considered appropriate for each case.Case Rep Oncol 2019;12:488 –493 (Source: Case Reports in Oncology)
Wed Jun 26, 2019 14:40
Lung cancer has the highest mortality of all cancers in the United States. The incidence of lung cancer with metastases to the skin varies between 1 –12%, with the highest incidence seen in men. Here, we present two cases of lung cancer presenting as skin metastasis. The first patient was an 80-year-old African American male who presented to the hospital for evaluation of a right upper back mass. A few months prior to admission, he was found t o have a left lung mass on CT scan of the chest, he underwent...
Wed Jun 26, 2019 14:39
Late recurrence of estrogen receptor (ER) positive breast cancer is common. When tissues from a recurrent or metastatic focus are available, re-evaluation of ER, progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2) status is recommended for treatment selection. This case report describes a 59-year-old woman who underwent surgery for left breast cancer, with a histopathological diagnosis of invasive ductal carcinoma (pathological stage T2N1aM0 Stage IIB, ER positive, PgR...
Wed Jun 26, 2019 14:39
Paraneoplastic Limbic Encephalitis Complicated with Small Cell Lung Cancer at the Time of Recurrence
In this study, we reported the case of a 74-year-old Japanese woman who developed PLE after partial remission of small cell lung cancer (SCLC) by first-line systemic chemotherapy. Brain magnetic resonance imaging showed no metastatic tumor or cerebrovascular disease. Anti-glutamic acid decarboxylase (GAD) and anti-amphiphysin antibodies were detected in her serum. She was diagnosed as having PLE related to the recurrence of SCLC and received high-dose glucocorticoid, and sequentially systemic chemotherapy...
Wed Jun 26, 2019 14:38
Conclusion: Cetuximab plus radiotherapy appears to be feasible and active in elderly patients unsuitable for cisplatin treatment. The treatment was supported by a favorable toxicity profile.Chemotherapy (Source: Chemotherapy)
Wed Jun 26, 2019 11:56
Conclusion: With lenvatinib therapy for HCC, the AFP levels of most patients had declined at 2 weeks, and at 4 weeks the AFP-sustained-reduction group demonstrated a higher objective response.Oncology (Source: Oncology)
Wed Jun 26, 2019 11:11
Authors: Mahalingam Carew Espitia Cool Giles de Jong Nawrocki Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis that may be a promising agent in cancer therapy due to its selectivity toward tumor cells. However, many cancer cells are resistant to TRAIL due to defects in apoptosis signaling or activation of survival pathways. We hypothesized that a disruption of pro-survival signaling cascades with the multi-tyrosine...
Wed Jun 26, 2019 00:00
Immunotherapy, Ahead of Print. (Source: Immunotherapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Wed Jun 26, 2019 00:00
Conclusion: In summary, our data highlight, the RT response of TNBC MDA-MB-231 cell line at a transcriptional level, in terms of activating radioresistance in these cells, as a model of late-stage BC. (Source: Cancer Genomics and Proteomics)
Wed Jun 26, 2019 00:00
ConclusionsThe combination of pIL-12 GET and pIRE not only enhanced survival but could bring a curative effect in wild type mice. This two-step treatment, named Immune-Gene Electro-Therapy (IGET), led to a systemic activation of the adaptive immune system and the development of an anti-tumor immune memory. (Source: Journal for Immunotherapy of Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 00:00
Authors: Chiabotto Gai Deregibus Camussi Extracellular vesicles (EVs) secreted in biological fluids contain several transcripts of the cell of origin, which may modify the functions and phenotype of proximal and distant cells. Cancer-derived EVs may promote a favorable microenvironment for cancer growth and invasion by acting on stroma and endothelial cells and may favor metastasis formation. The transcripts contained in cancer EVs may be exploited as biomarkers. Protein and...
Wed Jun 26, 2019 00:00
SummaryRenal leiomyoma (RL) is a rare benign tumor, usually presenting as a small asymptomatic lesion, frequently found during autopsy with a higher incidence in women (2:1). However, larger RL can become symptomatic and show structural changes (such as hemorrhagic and cystic degeneration), thus posing a diagnostic challenge. A 49-year-old woman with a recent history of weight loss and left flank pain was referred to our institution. An ultrasound exam revealed the presence of a complex mass at...
Wed Jun 26, 2019 00:00
ConclusionsAYA in the US experience disparities in cancer survival based on insurance status, independent of late stage of presentation. Patients age 26 ‐39 may be especially vulnerable to health outcomes associated with poor socioeconomic status, treatment disparities, and poor access to care. (Source: Cancer Medicine)
Wed Jun 26, 2019 00:00
ConclusionsThe current work will provide a framework and assurance for the diagnosis and treatment strategy of GRE to reduce complications and costs caused by unnecessary treatment. Additionally, it can serve as a reference for all professionals involved in the management of patients with GRE. (Source: Cancer Medicine)
Wed Jun 26, 2019 00:00
Conclusion: FOSB may be fused with SERPINE1, ACTB, or WWTR1 in pseudomyogenic hemangioendotheliomas. The resulting overexpression of FOSB fusion is a potentially useful marker that could be helpful in the diagnosis of these tumors. (Source: Cancer Genomics and Proteomics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Wed Jun 26, 2019 00:00
Authors: Gupta Chen Chaluvally-Raghavan Pradeep Increasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interactions among immune cells in the tumor microenvironment determine tumor progression. While the regulatory functions of T cells among...
Wed Jun 26, 2019 00:00
Minimal residual disease (MRD) in non Hodgkin’s lymphomas (NHLs) still represents matter of interest and debate: indeed, the new available treatments offer higher rates of complete responses and MRD negativity than in the past, with a positive impact on the long-term survival. Furthermore, the introduction of more sensitive and accurate molecular techniques, such as digital PCR (ddPCR) and the next generation sequencing techniques (NGS), increased the possibility of identifying molecular targets...
Wed Jun 26, 2019 00:00
Dinesh Manoharan, Sachidanand J Bharati, Mukesh K YadavSaudi Journal of Anaesthesia 2019 13(3):279-280 (Source: Saudi Journal of Anaesthesia)
Wed Jun 26, 2019 00:00
Conclusions: We successfully generated a miR-100 hepatocyte-specific knock-out mouse model. The malignant transformation related to HCC were observed in aged mice. Therefore, this model is suitable for investigating the mechanism of miR-100 inactivation contributing to HCC genesis in vivo. (Source: Frontiers in Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Wed Jun 26, 2019 00:00
In this study, we investigated these six markers in tumor microenvironment using an Aperio Imagescope system in the same TMAs. The joint prognostic power of markers was further evaluated and classified using a new algorithm named Weighted Dichotomizing. The classifier was verified via rigorous 10-fold cross validation. Statistical analysis of the protein expression indicated that in tumor-adjacent stroma FGFR1 and MYPT1 were significantly correlated with patient outcomes and LDHB showed the outcome-association...
Wed Jun 26, 2019 00:00
Conclusion: Our machine learning radiomics model showed promise for predicting response to nCRT in patients with LARC. Our predictive model based on the commonly used T2-weighted images on pelvic MRI scans has the potential to be adapted in clinical practice. (Source: Frontiers in Oncology)
Wed Jun 26, 2019 00:00
Hepatocellular carcinoma (HCC) is the fourth largest cause of cancer-related deaths worldwide with limited therapeutic interventions. Renewed interest in natural products as drug leads has resulted in a paradigm shift towards the rapid screening of medicinal plants for the discovery of new chemical entities. Rotundic acid (RA), a plant-derived triterpenoid, has been anecdotally reported to possess anti-inflammatory and cardio-protective abilities. The present study highlights the anti-cancer efficacy...
Wed Jun 26, 2019 00:00
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